2026-09-15T21:35:04Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1549892025-04-30T20:50:58Zcom_10366_4613com_10366_4576com_10366_3823col_10366_4616

Abdo, Hind Calvo Enrique, Laura Lopez, Jose Martinez Song, Jianren Zhang, Ming-Dong Usoskin, Dmitry El Manira, Abdeljabbar Adameyko, Igor Hjerling-Leffler, Jens Ernfors, Patrik 2019-08-16 An essential prerequisite for the survival of an organism is the ability to detect and respond to aversive stimuli. Current belief is that noxious stimuli directly activate nociceptive sensory nerve endings in the skin. We discovered a specialized cutaneous glial cell type with extensive processes forming a mesh-like network in the subepidermal border of the skin that conveys noxious thermal and mechanical sensitivity. We demonstrate a direct excitatory functional connection to sensory neurons and provide evidence of a previously unknown organ that has an essential physiological role in sensing noxious stimuli. Thus, these glial cells, which are intimately associated with unmyelinated nociceptive nerves, are inherently mechanosensitive and transmit nociceptive information to the nerve. http://hdl.handle.net/10366/154989 eng 2403 Bioquímica 2490 Neurociencias 2411 Fisiología Humana Specialized cutaneous Schwann cells initiate pain sensation info:eu-repo/semantics/article TEXT Gredos. Repositorio Documental de la Universidad de Salamanca Hispana