2026-08-26T07:50:13Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1551972025-04-30T20:45:40Zcom_10366_123989com_10366_4512com_10366_3823col_10366_123990

Hernández García, Ángela Patricia Juanes-Velasco, Pablo Landeira-Viñuela, Alicia Bareke, Halin Montalvillo Álvarez, Enrique Góngora Fernández, Rafael Fuentes García, Manuel 2024-02-02T09:37:27Z 2024-02-02T09:37:27Z 2021 http://hdl.handle.net/10366/155197 10.3390/CANCERS13112821 2072-6694 [EN]Immunogenic cell death (ICD) elicited by cancer therapy reshapes the tumor immune microenvironment. A long-term adaptative immune response can be initiated by modulating cell death by therapeutic approaches. Here, the major hallmarks of ICD, endoplasmic reticulum (ER) stress, and damage-associated molecular patterns (DAMPs) are correlated with ICD inducers used in clinical practice to enhance antitumoral activity by suppressing tumor immune evasion. Approaches to monitoring the ICD triggered by antitumoral therapeutics in the tumor microenvironment (TME) and novel perspective in this immune system strategy are also reviewed to give an overview of the relevance of ICD in cancer treatment. eng http://creativecommons.org/publicdomain/zero/1.0/ info:eu-repo/semantics/openAccess CC0 1.0 Universal Immunogenic cell death DAMPs apoptosis necroptosis autophagy tumor microenvironment natural products chemotherapy Restoring the Immunity in the Tumor Microenvironment: Insights into Immunogenic Cell Death in Onco-Therapies. info:eu-repo/semantics/article