2026-09-14T06:01:28Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1552102025-04-30T20:45:39Zcom_10366_123989com_10366_4512com_10366_3823col_10366_123990

Juanes-Velasco, Pablo Landeira-Viñuela, Alicia García-Vaquero, Marina L. Lecrevisse, Quentin Herrero, Raquel Ferruelo, Antonio Góngora Fernández, Rafael Corrales, Fernando Rivas Sanz, Javier de las Lorente, Jose A. Hernández García, Ángela Patricia Fuentes García, Manuel 2024-02-02T11:20:50Z 2024-02-02T11:20:50Z 2022 http://hdl.handle.net/10366/155210 10.3389/FIMMU.2022.732197 1664-3224 [EN]Acute respiratory distress syndrome (ARDS) is a severe pulmonary disease, which is one of the major complications in COVID-19 patients. Dysregulation of the immune system and imbalances in cytokine release and immune cell activation are involved in SARS-CoV-2 infection. Here, the inflammatory, antigen, and auto-immune profile of patients presenting COVID-19-associated severe ARDS has been analyzed using functional proteomics approaches. Both, innate and humoral responses have been characterized through acute-phase protein network and auto-antibody signature. Severity and sepsis by SARS-CoV-2 emerged to be correlated with auto-immune profiles of patients and define their clinical progression, which could provide novel perspectives in therapeutics development and biomarkers of COVID-19 patients. Humoral response in COVID-19 patients’ profile separates with significant differences patients with or without ARDS. Furthermore, we found that this profile can be correlated with COVID-19 severity and results more common in elderly patients. eng http://creativecommons.org/publicdomain/zero/1.0/ info:eu-repo/semantics/openAccess CC0 1.0 Universal SARS-CoV-2 COVID-19 ARDS auto-antibodies antigen acute-phase proteins proteomics microarrays SARS-CoV-2 Infection Triggers Auto-Immune Response in ARDS. info:eu-repo/semantics/article