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Gómez Álvarez, Marcelo Saldaña Fernández, Enrique 2024-02-07T10:04:07Z 2024-02-07T10:04:07Z 2016-08-01 2099-12-31 Gómez‐Álvarez, M., & Saldana, E. (2016). Different tonotopic regions of the lateral superior olive receive a similar combination of afferent inputs. Journal of Comparative Neurology, 524(11), 2230-2250. https://doi.org/10.1002/cne.23942 0021-9967 http://hdl.handle.net/10366/155471 10.1002/cne.23942 26659473 1096-9861 [EN]The mammalian lateral superior olive (LSO) codes disparities in the intensity of the sound that reaches the two ears by integrating ipsilateral excitation and contralateral inhibition, but it remains unclear what particular neuron types convey acoustic information to the nucleus. It is also uncertain whether the known conspicuous morphofunctional differences and gradients along the tonotopic axis of the LSO relate to qualitative and/or quantitative regional differences in its afferents. To clarify these issues, we made small, single injections of the neuroanatomical tracer biotinylated dextran amine (BDA) into different tonotopic regions of the LSO of albino rats and analyzed the neurons labeled retrogradely in brainstem auditory nuclei. We demonstrate that the LSO is innervated tonotopically by four brainstem neuron types: spherical bushy cells and planar multipolar neurons of the ipsilateral ventral cochlear nucleus, principal neurons of the ipsilateral medial nucleus of the trapezoid body, and small multipolar neurons of the contralateral ventral nucleus of the trapezoid body. Unexpectedly, the proportion of labeled neurons of each type was virtually identical in all cases, thus indicating that all tonotopic regions of the LSO receive a similar combination of inputs. Even more surprisingly, our data also suggest that the representation of frequencies in the LSO differs from that of the nuclei that innervate it: compared to the latter nuclei, the LSO seems to possess a relatively larger portion of its volume devoted to processing frequencies in the lower-middle part of the spectrum, and a relative smaller portion devoted to higher frequencies. J. Comp. Neurol. 524:2230-2250, 2016. © 2015 Wiley Periodicals, Inc. Instituto de Salud Carlos III (proyecto PI10/01803). Ministerio de Ciencia e Innovación (proyecto BFU2008-04197). Ministerio de Economía y Competitividad (proyecto BFU2013-43608-P). Junta de Castilla y León (proyectos GR221, SAN126/SA28/09 y SA343U14). eng Wiley Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/embargoedAccess Lateral superior olive Ventral cochlear nucleus Medial nucleus of the trapezoid body Ventral nucleus of the trapezoid body Spherical bushy cells Planar multipolar neurons Auditory Biotinylated dextran amine (BDA) Rat Rats Animals 2410.09 Neuroanatomía Humana 2411.13 Fisiología de la Audición animales ratas Different tonotopic regions of the lateral superior olive receive a similar combination of afferent inputs info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://doi.org/10.1002/cne.23942 Journal of Comparative Neurology 524 11 2230 2250