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oai:gredos.usal.es:10366/1563822026-01-12T10:04:40Zcom_10366_4074com_10366_4055com_10366_3946com_10366_3823col_10366_4075

Mariñas-Collado, Irene Rodríguez Díaz, Juan Manuel Santos Martín, María Teresa 2024-03-07T09:45:38Z 2024-03-07T09:45:38Z 2023 Irene Mariñas-Collado, Juan M. Rodríguez-Díaz, M. Teresa Santos-Martín, Optimal designs for a non-linear model for the pharmacokinetics of ethanol elimination in the human body, Chemometrics and Intelligent Laboratory Systems, Volume 238, 2023, 104839, ISSN 0169-7439, https://doi.org/10.1016/j.chemolab.2023.104839. (https://www.sciencedirect.com/science/article/pii/S0169743923000898) 0169-7439 http://hdl.handle.net/10366/156382 10.1016/j.chemolab.2023.104839 [EN]The equation most commonly used to estimate a person’s blood alcohol concentration after consuming alcoholic drinks assumes zero-order kinetics in the ethanol elimination phase. This implies that the elimination process occurs in the body at a uniform rate as a function of the ethyl-oxidation constant. The model, formulated by Widmark, does not consider the phase of increase in concentration, and approximates the phase of elimination in a linear way, which may be insufficient if the tests are carried out in the first phases of alcohol intake. In this paper, a non-linear model that fits the different phases of the pharmacokinetic process of ethanol in the human body (absorption, distribution, metabolism, and elimination) is proposed. Optimal experimental designs methods are used in order to find the most informative observation times for the estimation of the parameters of the model. eng info:eu-repo/semantics/openAccess Alcohol clearance Ethanol pharmacokinetics Widmark equation Non-linear models Optimal design of experiments D-optimality Covariance structure Optimal designs for a non-linear model for the pharmacokinetics of ethanol elimination in the human body. info:eu-repo/semantics/article