2026-09-16T08:07:14Zhttps://gredos.usal.es/oai/requestoai:gredos.usal.es:10366/1565962025-04-30T20:42:28Zcom_10366_156525com_10366_4512com_10366_3823col_10366_156526
2024-03-13T16:27:51Z
urn:hdl:10366/156596
Transcranial direct current stimulation intervention in Alzheimer’s disease and its follow-Up
Meléndez, Juan C.
Satorres, Encarna
Pitarque, Alfonso
Escudero, Joaquín
Delhom, Iraida
Navarro-Prados, Ana Belén
Alzheimer’s disease
Delayed memory
Short-term memory
Transcranial direct current stimulation
Working memory
[ENG]Background: Alzheimer’s disease (AD) stands as the prevailing type of dementia, marked by gradual memory loss and
cognitive decline. Transcranial direct current stimulation (tDCS) is a non-invasive method used to regulate cortical brain
function and has been explored as a potential treatment for cognitive impairment.
Objective: This study aimed to compare the effects of daily home-based active or sham tDCS on cognitive function in patients
with early-stage AD and its follow-up after one month.
Methods: The study involved a randomized, blinded, and controlled-placebo design, with 18 participants enrolled. The primary
outcome measures were general cognitive function, immediate, and delayed recall, and executive function. Participants
included in the study were randomly assigned to the anodal and sham tDCS groups. Participants were assessed before and
after the intervention and one month after the end of treatment. The home-based intervention was applied for 5 consecutive
days, daily.
Results: The results showed a significant interaction between the active and sham groups; in particular, improvements in
MMSE scores, immediate memory and delayed recall were observed at one-month follow-up in the active group.
Conclusions: The positive effects of tDCS on cognitive function in AD patients observed suggest that tDCS may induce
long-term neuroplastic changes, leading to sustained improvements in cognitive abilities
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2024-03-13T16:27:51Z
2023
info:eu-repo/semantics/article
1875-8908
http://hdl.handle.net/10366/156596
10.3233/JAD-230826
eng
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
IOS Press