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oai:gredos.usal.es:10366/1568352025-04-30T20:34:42Zcom_10366_156566com_10366_4512com_10366_3823col_10366_156568

Djermane, Rania Nieto Jiménez, Celia Vega Moreno, Milena Amparo Martín del Valle, Eva María 2024-03-21T08:14:26Z 2024-03-21T08:14:26Z 2023 Djermane R, Nieto C, Vega MA, del Valle EMM. (2023). Antibody-Loaded Nanoplatforms for Colorectal Cancer Diagnosis and Treatment: An Update. Pharmaceutics, 15(5):1514. https://doi.org/10.3390/pharmaceutics15051514 http://hdl.handle.net/10366/156835 10.3390/pharmaceutics15051514 1999-4923 [EN]At present, colorectal cancer (CRC) is the second deadliest type of cancer, partly because a high percentage of cases are diagnosed at advanced stages when tumors have already metastasized. Thus, there is an urgent need to develop novel diagnostic systems that allow early detection as well as new therapeutic systems that are more specific than those currently available. In this context, nanotechnology plays a very important role in the development of targeted platforms. In recent decades, many types of nanomaterials with advantageous properties have been used for nanooncology applications and have been loaded with different types of targeted agents, capable of recognizing tumor cells or biomarkers. Indeed, among the different types of targeted agents, the most widely used are monoclonal antibodies, as the administration of many of them is already approved by the main drug regulatory agencies for the treatment of several types of cancer, including CRC. In this way, this review comprehensively discusses the main drawbacks of the conventional screening technologies and treatment for CRC, and it presents recent advances in the application of antibody-loaded nanoplatforms for CRC detection, therapy or theranostics applications. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional Colorectal cancer Nanomedicine Monoclonal antibodies Biosensors Nanoimaging Drug delivery systems Combination nanotherapy Theranostics Antibody-Loaded Nanoplatforms for Colorectal Cancer Diagnosis and Treatment: An Update info:eu-repo/semantics/article