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oai:gredos.usal.es:10366/1594622025-04-30T19:36:27Zcom_10366_4019com_10366_3947com_10366_3946com_10366_3823col_10366_4020

00925njm 22002777a 4500 dc Novo Veleiro, Ignacio author Herrera-Flores, Javier author Rosón Hernández, Beatriz author Medina García, José-A. author Muga Bustamante, Roberto author Fernández Solá, Joaquín author Martín González, M. Candelaria author Seco Hernández, Elena author Suárez Cuervo, Carlos author Mateos Díaz, Ana María author Monte Secades, Rafael author Machado Prieto, Begoña author Puerta Louro, Rubén author Prada González, Cristina author Fernández Rial, Álvaro author Sabio Repiso, Patricia author Vázquez Vigo, Rocío author Antolí Royo, Ana Cristina author Gomila Grange, Aina author Felipe Pérez, Nieves-C. author Sanvisens Bergé, Arantza author Antúnez Jorge, Emilia author Fernández Rodríguez, Camino-M. author Alvela-Suárez, Lucía author Fidalgo Navarro, Alba author Castro, Joaquín author Polvorosa Gómez, María A. author del Valle Sánchez, Mario author Lopez Castro, José author Chamorro Fernández, Antonio Javier author Marcos Martín, Miguel author 2022 [EN] Background: data regarding the association between Wernicke encephalopathy (WE) and alcoholic liver disease (ALD) are scarce in spite of alcohol consumption being the main risk factor for WE. Aims: to describe the frequency of ALD in a cohort of patients diagnosed with WE and alcohol use disorders (AUDs) and to compare the characteristics of WE patients with and without ALD. Methods: we conducted an observational study in 21 centers through a nationwide registry of the Spanish Society of Internal Medicine. WE Caine criteria were applied and demographic, clinical, and outcome variables were analyzed. Results: 434 patients were included in the study, of which 372 were men (85.7%), and the mean age was 55 ± 11.8 years. ALD was present in 162 (37.3%) patients and we found a higher percentage of cases with tremor, flapping and hallucinations in the ALD group. A total of 22 patients (5.0%) died during admission (7.4% with ALD vs 3.7% without ALD; P = 0.087). Among the ALD patients, a relationship between mortality and the presence of anemia (Odds ratio [OR]=4.6 Confidence interval [CI]95% 1.1–18.8; P = 0.034), low level of consciousness (OR=4.9 CI95% 1.1–21.2; P = 0.031) and previous diagnosis of cancer (OR=10.3 CI95% 1.8–59.5; P = 0.009) was detected. Complete recovery was achieved by 27 patients with ALD (17.8%) and 71 (27.8%) without ALD (P = 0.030). Conclusion: the association of WE and ALD in patients with AUDs is frequent and potentially linked to differences in clinical presentation and to poorer prognosis, as compared to alcoholic patients with WE without ALD. Novo-Veleiro, I., Herrera-Flores, J., Rosón-Hernández, B., Medina-García, J.-A., Muga, R., Fernández-Solá, J., Martín-González, M.-C., Seco-Hernández, E., Suárez-Cuervo, C., Mateos-Díaz, A.-M., Monte-Secades, R., Machado-Prieto, B., Puerta-Louro, R., Prada-González, C., Fernández-Rial, Á., Sabio-Repiso, P., Vázquez-Vigo, R., Antolí-Royo, A.-C., Gomila-Grange, A., … Marcos, M. (2022). Alcoholic Liver Disease Among Patients with Wernicke Encephalopathy: A Multicenter Observational Study. Drug and Alcohol Dependence, 230, 109186. https://doi.org/10.1016/j.drugalcdep.2021.109186 0376-8716 http://hdl.handle.net/10366/159462 10.1016/j.drugalcdep.2021.109186 1879-0046 Wernicke encephalopathy Alcoholic liver disease Alcohol use disorders Alcoholic liver disease among patients with Wernicke Encephalopathy: a multicenter observational study