2026-09-14T21:17:09Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1608972025-04-30T19:28:31Zcom_10366_3974com_10366_3947com_10366_3946com_10366_3823col_10366_3975

González González, María García García, Jacinto Alcázar Montero, José Antonio Gutiérrez Troncoso, María Laura Gónzalez, Luis M. Bengoechea Miranda, Oscar Abad Hernández, María Mar Santos Briz Terrón, Ángel Blanco Muñez, Óscar Javier Martín, Manuela Rodríguez, Ana Fuentes García, Manuel Muñoz Bellvís, Luis Orfao de Matos Correia e Vale, José Alberto Sayagués Manzano, José María 2024-12-03T09:50:38Z 2024-12-03T09:50:38Z 2014 González-González, M., Garcia, J., Alcazar, J. A., Gutiérrez, M. L., Gónzalez, L. M., Bengoechea, O., Abad, M. M., Santos-Briz, A., Blanco, O., Martín, M., Rodríguez, A., Fuentes, M., Muñoz-Bellvis, L., Orfao, A., y Sayagues, J. M. (2014). Association between the cytogenetic profile of tumor cells and response to preoperative radiochemotherapy in locally advanced rectal cancer. Medicine, 93(26), e153. https://doi.org/10.1097/MD.0000000000000153 0025-7974 1536-5964 http://hdl.handle.net/10366/160897 10.1097/MD.0000000000000153 [EN]Neoadjuvant radiochemotherapy to locally advanced rectal carcinoma patients has proven efficient in a high percentage of cases. Despite this, some patients show nonresponse or even disease progression. Recent studies suggest that different genetic alterations may be associated with sensitivity versus resistance of rectal cancer tumor cells to neoadjuvant therapy. We investigated the relationship between intratumoral pathways of clonal evolution as assessed by interphase fluorescence in situ hybridization (51 different probes) and response to neoadjuvant radiochemotherapy, evaluated by Dworak criteria in 45 rectal cancer tumors before (n ¼ 45) and after (n ¼ 31) treatment. Losses of chromosomes 1p (44%), 8p (53%), 17p (47%), and 18q (38%) and gains of 1q (49%) and 13q (75%) as well as amplification of 8q (38%) and 20q (47%) chromosomal regions were those specific alterations found at higher frequencies. Significant association (P< 0.05) was found between alteration of 1p, 1q, 11p, 12p, and 17p chromosomal regions and degree of response to neoadjuvant therapy. A clear association was observed between cytogenetic profile of the ancestral tumor cell clone and response to radiochemotherapy; cases presenting with del(17p) showed a poor response to neoadjuvant treatment (P ¼ 0.03), whereas presence of del(1p) was more frequently observed in responder patients (P ¼ 0.0002). Moreover, a significantly higher number of copies of chromosomes 8q (P ¼ 0.004), 13q (P ¼ 0.003), and 20q (P ¼ 0.002) were found after therapy versus paired pretreatment rectal cancer samples. Our results point out the existence of an association between tumor cytogenetics and response to neoadjuvant therapy in locally advanced rectal cancer. Further studies in larger series of patients are necessary to confirm our results . eng Lippincott, Williams & Wilkins Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Radioquimioterapia Recto Carcinoma Cáncer rectal Celulas tumorales Radiotherapy Electrochemotherapy Carcinoid Tumor Rectal Diseases 3207.13 Oncología 2407 Biología Celular 2302.06 Quimioterapia 3201.12 Radioterapia Electroquimioterapia Enfermedades del recto Radioterapia Tumor carcinoide Association Between the Cytogenetic Profile of Tumor Cells and Response to Preoperative Radiochemotherapy in Locally Advanced Rectal Cancer info:eu-repo/semantics/article info:eu-repo/semantics/draft https://journals.lww.com/md-journal/fulltext/2014/12010/association_between_the_cytogenetic_profile_of.3.aspx Medicine 93 26 e153