2026-09-06T18:58:56Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1609892025-04-30T19:28:21Zcom_10366_3974com_10366_3947com_10366_3946com_10366_3823col_10366_3975

Perea García, José Martí, Marc Espin, Eloy Hernández-Villafranca, Sergio Orihuela, Pilar Vidal Tocino, María del Rosario Alcázar Montero, José Antonio Vivas, Alfredo Narvaez, Cristina Prieto, Isabel Asensio, Luis López-Rojo, Irene Encinas Garcia, Sara Hurtado, Elena Jiménez, Luis M. Jiménez, Fernando Cavero, Adriana Álvaro, Edurne Fuenmayor, Maria Luisa Jiménez-Toscano, Marta Iglesias Comas, Mar Balaguer, Francesc Daca, Maria Ballestero, Araceli Die Trill, Javier Sanz, Gonzalo Sanz López, Rodrigo Melone, Sirio Rueda, Jose A. Brandáriz, Lorena Valverde, Ignacio Arredondo, Jorge Pastor, Carlos Garcia-Olmo, Damian Malats, Nuria Urioste, Miguel González Sarmiento, Rogelio Spinelli, Antonino Holowatyj, Andreana N. Perea, Jose Marti, Marc Hernandez-Villafranca, Sergio Vidal Tocino, María del Rosario Alcázar Montero, José Antonio López Rojo, Irene Jiménez, Luis M Alvaro, Edurne Jiménez Toscano, Marta Rueda, Jose A Brandariz, Lorena González Sarmiento, Rogelio Holowatyj, Andreana N 2024-12-10T09:59:19Z 2024-12-10T09:59:19Z 2021 Perea, J., Marti, M., Espin, E., Hernandez-Villafranca, S., Orihuela, P., Vidal Tocino, R., Alcazar, J. A., Vivas, A., Narvaez, C., Prieto, I., Asensio, L., López Rojo, I., Encinas Garcia, S., Hurtado, E., Jiménez, L. M., Jiménez, F., Cavero, A., Alvaro, E., Fuenmayor, M. L., … Holowatyj, A. N. (2021). Cohort profile: The Spanish Early-onset Colorectal Cancer (Secoc) cohort: a multicentre cohort study on the molecular basis of colorectal cancer among young individuals in Spain. BMJ Open, 11(12), e055409. https://doi.org/10.1136/bmjopen-2021-055409 2044-6055 http://hdl.handle.net/10366/160989 10.1136/bmjopen-2021-055409 2044-6055 [EN]Purpose The Spanish Early-onset Colorectal Cancer (SECOC) study is a multicentre prospective cohort established in Spain to investigate the molecular basis of early-onset colorectal cancer (EOCRC), including metabolic alterations. Participants 220 patients with EOCRC have been enrolled since January 2019 through 18 centres across Spain. Individual-level data were collected by questionnaire, including lifestyle and other colorectal cancer-related factors. Medical record review was performed to capture clinical, histopathological and familial cancer history data. Biospecimen collection (blood, stool, tissue) at diagnosis and at various time points across treatment, as applicable, is also completed. Findings to date Participants had a median age of 44 years (range 14-49), and the majority are men (60%), with individuals age 40-49 years at EOCRC diagnosis being over-represented. Forty-three per cent of participants were diagnosed with a tumour in the rectosigmoid junction/rectum. Nearly two-thirds of EOCRC cases (64%) were diagnosed with advanced stage (III-IV) disease, and 28% of cases had no reported familial history of cancer. Future plans We are actively recruiting and observing participants; we plan to administer follow-up questionnaires and perform additional biospecimen collection. This prospective cohort offers a unique, rich resource for research on EOCRC aetiologies and will contribute to larger international efforts to disentangle the rising disease burden. eng http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess Atribución-NoComercial 4.0 Internacional Colorectal cancer Metabolic alterations Molecular basis Cohort profile: the Spanish Early-onset Colorectal Cancer (SECOC) cohort: a multicentre cohort study on the molecular basis of colorectal cancer among young individuals in Spain info:eu-repo/semantics/article