2026-09-14T14:43:12Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1610902025-04-30T19:35:53Zcom_10366_4019com_10366_3947com_10366_3946com_10366_3823col_10366_4020

Cameron, Cheryl M Cameron, Mark J Bermejo Martín, Jesús Francisco Ran, Longsi Xu, Luoling Turner, Patricia V Ran, Ran Danesh, Ali Fang, Yuan Chan, Pak-Kei M Mytle, Nutan Sullivan, Timothy J Collins, Tassie L Johnson, Michael G Medina, Julio C Rowe, Thomas Kelvin, David J 2024-12-12T10:10:12Z 2024-12-12T10:10:12Z 2008-11 http://hdl.handle.net/10366/161090 10.1128/JVI.00691-08 18684821 1098-5514 [EN]How viral and host factors contribute to the severe pathogenicity of the H5N1 subtype of avian influenza virus infection in humans is poorly understood. We identified three clusters of differentially expressed innate immune response genes in lungs from H5N1 (A/Vietnam/1203/04) influenza virus-infected ferrets by oligonucleotide microarray analysis. Interferon response genes were more strongly expressed in H5N1-infected ferret lungs than in lungs from ferrets infected with the less pathogenic H3N2 subtype. In particular, robust CXCL10 gene expression in H5N1-infected ferrets led us to test the pathogenic role of signaling via CXCL10's cognate receptor, CXCR3, during H5N1 influenza virus infection. Treatment of H5N1-infected ferrets with the drug AMG487, a CXCR3 antagonist, resulted in a reduction of symptom severity and delayed mortality compared to vehicle treatment. We contend that unregulated host interferon responses are at least partially responsible for the severity of H5N1 infection and provide evidence that attenuating the CXCR3 signaling pathway improves the clinical course of H5N1 infection in ferrets. eng Attribution-NonCommercial-NoDerivs 3.0 Unported http://creativecommons.org/licenses/by-nc-nd/3.0/ info:eu-repo/semantics/openAccess Gene Expression Profiling Chemokine CXCL10 Influenza A Virus, H3N2 Subtype Orthomyxoviridae Infections Survival Analysis Lung Influenza A virus Gene Expression Profiling Animals Chemokine CXCL10 Humans Survival Analysis Orthomyxoviridae Infections Ferrets infecciones por Orthomyxoviridae perfiles de expresión génica análisis de supervivencia animales hurones humanos pulmón quimiocina CXCL10 virus de la influenza A Gene expression analysis of host innate immune responses during Lethal H5N1 infection in ferrets. info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://doi.org/10.1128/JVI.00691-08 Journal of virology 82 22 11308