2026-09-14T05:37:48Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1614642025-04-30T19:35:28Zcom_10366_4019com_10366_3947com_10366_3946com_10366_3823col_10366_4020

Martí Chillón, Gerardo Javier Muntión, Sandra Preciado Pérez, Silvia Osugui, Lika Navarro Bailón, Almudena González Robledo, Javier Sagredo, Víctor Blanco Blanco, Juan Francisco Sánchez-Guijo Martín, Fermín 2025-01-09T10:23:24Z 2025-01-09T10:23:24Z 2023-01 Martí-Chillón GJ, Muntión S, Preciado S, Osugui L, Navarro-Bailón A, González-Robledo J, Sagredo V, Blanco JF, Sánchez-Guijo F. Therapeutic potential of mesenchymal stromal/stem cells in critical-care patients with systemic inflammatory response syndrome. Clin Transl Med. 2023 Jan;13(1):e1163. doi: 10.1002/ctm2.1163. PMID: 36588089; PMCID: PMC9806020. 2001-1326 http://hdl.handle.net/10366/161464 10.1002/ctm2.1163 2001-1326 [EN] Despite notable advances in the support and treatment of patients admitted to the intensive care unit (ICU), the management of those who develop a systemic inflammatory response syndrome (SIRS) still constitutes an unmet medical need. Main body: Both the initial injury (trauma, pancreatitis, infections) and the derived uncontrolled response promote a hyperinflammatory status that leads to systemic hypotension, tissue hypoperfusion and multiple organ failure. Mesenchymal stromal/stem cells (MSCs) are emerging as a potential therapy for severe ICU patients due to their potent immunomodulatory, anti-inflammatory, regenerative and systemic homeostasis-regulating properties. MSCs have demonstrated clinical benefits in several inflammatory-based diseases, but their role in SIRS needs to be further explored. Conclusion: In the current review, after briefly overviewing SIRS physiopathology, we explore the potential mechanisms why MSC therapy could aid in the recovery of this condition and the pre-clinical and early clinical evidence generated to date. instituto de Salud Carlos III (ISCIII) Gerencia Regional de Salud de Castilla y León Ayuntamiento de Salamanca Ministerio de Universidades Fundación Española de Hematología y Hemoterapia eng John Wiley & Sons Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess cellular therapy immunomodulation intensive care mesenchymal stromal/stem cells MSCs sepsis SIRS systemic inflammatory response syndrome Intensive Care Mesenchymal Stromal Cells Mesenchymal Stem Cell Transplantation Systemic Inflammatory Response Syndrome Cell- and Tissue-Based Therapy 3205 Medicina Interna 3205.04 Hematología 3213.15 Traumatología 2410 Biología Humana cuidados intensivos células del estroma mesenquimatoso síndrome de respuesta inflamatoria sistémica trasplante de células madre mesenquimatosas tratamientos basados en células y tejidos Therapeutic potential of mesenchymal stromal/stem cells in critical‐care patients with systemic inflammatory response syndrome info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://doi.org/10.1002/ctm2.1163 PI19/01455 GRS 164/A/17 2019/00098/001 FPU18/03533 RD16/0011/0015 RD21/0017/0006 Clinical and Translational Medicine 13 1 e1163