2026-09-14T20:16:53Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1614932026-06-19T12:28:23Zcom_10366_4019com_10366_3947com_10366_3946com_10366_3823col_10366_4020

Anguera, Ignasi Faga, Valentina Jiménez Candil, Francisco Javier Moreno-Weidmann, Zoraida Santos-Ortega, Alba Jiménez-Jáimez, Juan Rodríguez-García, Julián Claver, Eduard Mercé, Jordi Jovells-Vaque, Silvia Diez-López, Carles Hernández, Jesús Rivas-Gandara, Nuria Macías, Rosa García-Cosculluela, Danae Comin-Colet, Josep Di Marco, Andrea 2025-01-09T12:05:56Z 2025-01-09T12:05:56Z 2025-01-01 Anguera, I., Faga, V., Jimenez-Candil, J., Moreno-Weidmann, Z., Santos-Ortega, A., Jimenez-Jaimez, J., Rodriguez-García, J., Claver, E., Mercé, J., Jovells-Vaque, S., Diez-Lopez, C., Hernández, J., Rivas-Gandara, N., Macías, R., García-Cosculluela, D., Comin-Colet, J., & Di Marco, A. (2025). Late gadolinium enhancement and outcome of cardiac resynchronization therapy in non-ischemic cardiomyopathy. International Journal of Cardiology, 418. https://doi.org/10.1016/J.IJCARD.2024.132618 http://hdl.handle.net/10366/161493 10.1016/j.ijcard.2024.132618 39384095 1874-1754 Article 132618 [EN]It is uncertain whether CRT with defibrillator (CRTD) is superior to CRT with pacemaker (CRTP) in NICM. Patients with low arrhythmic risk and high probability of response to CRT might be ideal candidates for CRTP. We aimed to evaluate predictors of ventricular arrhythmias and of echocardiographic response to cardiac resynchronization therapy (CRT) in non-ischemic cardiomyopathy (NICM). Multicenter, retrospective observational study of NICM patients with left ventricular ejection fraction (LVEF) ≤35 %, cardiac magnetic resonance with analysis of late gadolinium enhancement (LGE) available and de-novo CRT implant. Echocardiographic response to CRT was defined as an improvement in LVEF ≥10 %. The combined arrhythmic endpoint included sustained ventricular tachycardia, appropriate ICD therapy, resuscitated cardiac arrest and sudden death. We included 167 patients, with a median follow-up of 63 months. LGE was present in 77 (46 %). Response to CRT occurred in 68 % of patients, more frequently in LGE- than in LGE+ (81 % vs 53 %, p < 0.001). Absence of LGE (OR 3.4, p = 0.002), was an independent predictor of response to CRT. The arrhythmic endpoint occurred in 19 patients (11 %). Among LGE- patients there were zero arrhythmic events as compared to a 25 % cumulative incidence in LGE+ (p < 0.001). Presence of LGE (HR 22.5, p < 0.001), was an independent predictor of the arrhythmic endpoint. Absence of LGE identifies patients at minimal arrhythmic risk and with high probability of response to CRT. Thus, they might be ideal candidates to CRT-P. eng Elsevier Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Cardiac magnetic resonance Late gadolinium enhancement Non-ischemic cardiomyopathy Cardiac resynchronization therapy Ventricular arrhythmias Cardiomyopathies Gadolinium Aged Treatment Outcome Humans Follow-Up Studies Middle Aged Cardiac Resynchronization Therapy Magnetic Resonance Imaging Contrast Media Retrospective Studies medios de contraste resultado del tratamiento imagen por resonancia magnética humanos terapia de resincronización cardíaca anciano mediana edad estudios de seguimiento gadolinio estudios retrospectivos miocardiopatías Late gadolinium enhancement and outcome of cardiac resynchronization therapy in non-ischemic cardiomyopathy info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://doi.org/10.1016/J.IJCARD.2024.132618 International Journal of Cardiology 418 132618