2026-09-17T16:03:02Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1619292026-02-13T11:39:01Zcom_10366_4019com_10366_3947com_10366_3946com_10366_3823col_10366_4020

Juanes Velasco, Pablo Landeira-Viñuela, Alicia García-Vaquero, Marina L. Lecrevisse, Quentin Herrero, Raquel Ferruelo, Antonio Góngora, Rafael Corrales, Fernando Rivas Sanz, Javier de las Lorente, Jose A. Hernández, Ángela-Patricia Fuentes, Manuel 2022-01-28 Artículo [EN]Acute respiratory distress syndrome (ARDS) is a severe pulmonary disease, which is one of the major complications in COVID-19 patients. Dysregulation of the immune system and imbalances in cytokine release and immune cell activation are involved in SARS-CoV-2 infection. Here, the inflammatory, antigen, and auto-immune profile of patients presenting COVID-19-associated severe ARDS has been analyzed using functional proteomics approaches. Both, innate and humoral responses have been characterized through acute-phase protein network and auto-antibody signature. Severity and sepsis by SARS-CoV-2 emerged to be correlated with auto-immune profiles of patients and define their clinical progression, which could provide novel perspectives in therapeutics development and biomarkers of COVID-19 patients. Humoral response in COVID-19 patients’ profile separates with significant differences patients with or without ARDS. Furthermore, we found that this profile can be correlated with COVID-19 severity and results more common in elderly patients. http://hdl.handle.net/10366/161929 eng Frontiers Media S.A. 2412 Inmunología SARS-CoV-2 infection triggers auto-immune response in ARDS info:eu-repo/semantics/article TEXT Gredos. Repositorio Documental de la Universidad de Salamanca Hispana