2026-09-15T23:28:27Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1619782026-06-19T08:37:34Zcom_10366_4019com_10366_3947com_10366_3946com_10366_3823col_10366_4020

Queiro, Rubén Seoane-Mato, Daniel Laiz, Ana Galíndez Agirregoikoa, Eva Montilla Morales, Carlos Alberto Park, Hye-Sang Pinto-Tasende, José A. Baute, Juan J. Bethencourt Ibáñez, Beatriz Joven Toniolo, Elide Ramírez, Julio Serrano García, Ana Arthritis Psoriatic Quality of life Predictive model Machine learning [EN]To evaluate which patient and disease characteristics are associated with the perception of high-impact disease (PsAID ≥4) in recent-onset psoriatic arthritis. We performed a multicenter observational prospective study (2-year follow-up, regular annual visits). The study population comprised patients aged ≥18 years who fulfilled the CASPAR criteria and less than 2 years since the onset of symptoms. The dataset was generated using data for each patient at the 3 visits (baseline, first year, and second year of follow-up) matched with the PsAID values at each of the 3 visits. PsAID was categorized into two groups (<4 and ≥4). We trained a logistic regression model and random forest-type and XGBoost machine learning algorithms to analyze the association between the outcome measure and the variables selected in the bivariate analysis. A k-fold cross-validation with k = 5 was performed. The sample comprised 158 patients. Of the patients who attended the clinic, 45.8% scored PsAID ≥4 at baseline; 27.1%, at the first follow-up visit, and in 23.0%, at the second follow-up visit. The variables associated with PsAID ≥4 were, in decreasing order of importance: HAQ, pain, educational level, and physical activity. Higher HAQ (logistic regression coefficient 10.394; IC95% 7.777,13.011), higher pain (5.668; 4.016, 7.320), lower educational level (-2.064; -3.515, -0.613) and high level of physical activity (1.221; 0.158, 2.283) were associated with a higher frequency of PsAID ≥4. The mean values of the measures of validity of the algorithms were all ≥85%. Despite the higher weight given to pain when scoring PsAID, we observed a greater influence of physical function on disease impact. 2025-01-20 2025-01-20 2022-12 info:eu-repo/semantics/article Queiro, R., Seoane-Mato, D., Laiz, A., Agirregoikoa, E. G., Montilla, C., Park, H.-S., Pinto-Tasende, J. A., Baute, J. J. B., Ibáñez, B. J., Toniolo, E., Ramírez, J., & García, A. S. (2022). Characteristics associated with the perception of high-impact disease (PsAID ≥4) in patients with recent-onset psoriatic arthritis. Machine learning-based model. Seminars in Arthritis and Rheumatism, 57. https://doi.org/10.1016/J.SEMARTHRIT.2022.152097 0049-0172 http://hdl.handle.net/10366/161978 10.1016/J.SEMARTHRIT.2022.152097 36113222 1532-866X eng https://doi.org/10.1016/J.SEMARTHRIT.2022.152097 http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier