2026-09-14T13:25:23Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1622872025-06-04T11:01:07Zcom_10366_3983com_10366_3947com_10366_3946com_10366_3823col_10366_3984

Rodrigo Gonzalo, María José González Manzano, Susana Méndez Sánchez, Roberto Santos Buelga, Celestino Recio Rodríguez, José Ignacio 2025-01-22T12:27:39Z 2025-01-22T12:27:39Z 2022 Rodrigo-Gonzalo, M. J., González-Manzano, S., Mendez-Sánchez, R., Santos-Buelga, C., & Recio-Rodríguez, J. I. (2022). Effect of Polyphenolic Complements on Cognitive Function in the Elderly: A Systematic Review. Antioxidants, 11(8), 1549. https://doi.org/10.3390/antiox11081549 http://hdl.handle.net/10366/162287 10.3390/ANTIOX11081549 2076-3921 [ENG]Polyphenols have been shown to be effective against many chronic diseases. These compounds could have a beneficial effect at the cognitive level. The exact mechanism by which they provide positive effects at the cognitive level is not well known, but it is believed that they could counteract neuroinflammation. The objective of this study is to review nutritional interventions that include foods or supplements rich in flavanols, flavonols, or stilbenes to the usual diet on cognitive deterioration in people over 50 years of age. Clinical trials published in PubMed and Web of Science from 1 March 2010 to 1 March 2020 were explored, from which 14 studies were selected. All of them showed some improvement after the intervention. In interventions with flavanols and stilbenes, relevant improvements have been observed both in healthy patients and in patients with established cognitive impairment. Most studies agree that the greatest benefits are found with high doses and longer duration treatments. The changes were fundamentally assessed through cognitive tests, and in some of the studies, through magnetic resonance imaging (fMRI). The type of cognitive test used to assess the effect of the intervention was revealed to be critical. Several studies have also shown improvements in analytical parameters and blood pressure. The financial support by Gerencia Regional de Salud de Castilla y León (GRS 2381/A/21), Ministerio de Ciencia e Innovación (PID2019-106167RB-I00) and Junta de Castilla y León (SA093P20 and CLU-2018-04) is acknowledged. The financial support by Gerencia Regional de Salud de Castilla y León (GRS 2381/A/21), Ministerio de Ciencia e Innovación (PID2019-106167RB-I00) and Junta de Castilla y León (SA093P20 and CLU-2018-04) is acknowledged. eng https://www.mdpi.com/2076-3921/11/8/1549 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/embargoedAccess flavonoids flavanols stilbenes cognitive function cognitive impairment neurophysicological function Flavonoids Stilbenes flavonoides estilbenos Effect of polyphenolic complements on cognitive function in the elderly: a systematic review info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://doi.org/10.3390/antiox11081549 Antioxidants 11 8 1549