2026-09-16T22:43:37Zhttps://gredos.usal.es/oai/requestoai:gredos.usal.es:10366/1670702025-09-20T02:03:23Zcom_10366_143088com_10366_123103com_10366_3823com_10366_4377com_10366_4349com_10366_3946com_10366_4756com_10366_4746col_10366_143114col_10366_4378col_10366_68518
Gestión del Repositorio Documental de la Universidad de Salamanca
advisor
Martín del Valle, Eva María
advisor
Vega Moreno, Milena Amparo
author
Djermane, Rania
2025-09-18T08:26:24Z
2025-09-18T08:26:24Z
2025
http://hdl.handle.net/10366/167070
10.14201/gredos.167070
[EN] In recent years, interest in nanomedicine, particularly in the use of polymeric nanoparticles, has grown significantly as an innovative and effective strategy for cancer treatment. Although conventional chemotherapy has proven to be effective, it presents significant limitations, such as systemic toxicity, lack of specificity, and the occurrence of adverse reactions. In this context, nanomedicine offers a promising alternative by enabling targeted drug delivery through nanoparticles (NPs), minimizing damage to healthy tissues, reducing multidrug resistance, and facilitating treatment personalization.
In this regard, the present thesis investigates the feasibility of using polydopamine nanoparticles (PDA NPs), a type of polymeric NPs, for cancer detection and treatment, aiming to enhance therapeutic efficacy while minimizing systemic adverse effects. Despite promising results in preclinical studies, challenges remain regarding large-scale production, protein corona formation, and potential toxicity, which must be addressed before clinical application. Therefore, this investigation focuses on the synthesis, characterization, optimization, and validation of PDA NP-based drug delivery systems for the treatment of metastatic colorectal cancer and HER-2 positive breast cancer, with an emphasis on biocompatibility and tumor specificity.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Tesis y disertaciones académicas
Universidad de Salamanca (España)
Tesis Doctoral
Academic dissertations
Nanopartículas
Cáncer colorrectal
Mamas Cáncer
Medicamentos Administración
Nanoparticles
Colorectal Cancer
Breast Cancer
Drug Administration
Study of the Physicochemical Properties of Polydopamine Nanoparticles and Their Application in the Development of Tailored Drug Delivery Nanocarriers for Cancer Theraphy
info:eu-repo/semantics/doctoralThesis
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
URL
https://gredos.usal.es/bitstream/10366/167070/1/Djermane%2c%20Rania.pdf
File
MD5
e80f18dd223b6c1de43ed7feafe53168
16416521
application/pdf
Djermane, Rania.pdf
URL
https://gredos.usal.es/bitstream/10366/167070/4/Djermane%2c%20Rania.pdf.txt
File
MD5
d3893cb980e1397d2c14b5c1675b359c
545951
text/plain
Djermane, Rania.pdf.txt