2026-09-16T05:46:47Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1680252026-01-27T08:55:32Zcom_10366_3948com_10366_3947com_10366_3946com_10366_3823col_10366_3949

Carretero Hernández, Marta Herráez Aguilar, Elisa Hernández González, David Díez Castro, David Catalano Iniesta, Leonardo García Barrado, Josefa Blanco Barco, Enrique José Carretero González, José 2025-11-28T11:58:14Z 2025-11-28T11:58:14Z 2025-05-23 Carretero-Hernández, M., Herráez, E., Hernández-González, D., Díez-Castro, D., Catalano-Iniesta, L., García-Barrado, J., ... & Carretero, J. (2025). Lifetime Variations of Prolactin Receptor Isoforms mRNA in the Hippocampus and Dentate Gyrus of the Rat—Effects of Aging. International Journal of Molecular Sciences, 26(11), 5023. 1661-6596 http://hdl.handle.net/10366/168025 10.3390/ijms26115023 1422-0067 [EN]Prolactin is a hormone for which actions on the central nervous system such as neurogenesis and neuroprotection have been described by acting on specific receptors. The presence of prolactin receptors in the brain, including the hippocampus, is well documented; however, it is unknown whether these receptors change with age and whether they are related to sex. For this reason, a study of the expression of prolactin receptors, in the short and long isoforms, in the hippocampus of male and female rats has been carried out by qPCR and in situ hybridization, with a densitometric analysis in the following life stages: prepubertal, postpubertal, young adult, adult, and old. The results revealed the greater expression of the long isoform than of the short isoform in males, but not in females, with significant differences between males and females and in the different life stages studied. With significant differences, the highest expression of both isoforms appeared in male rats in the postpubertal stage, and the lowest expression was observed in adult and old animals. In situ hybridization showed differences in the localization of PRLR mRNA expression in CA1, CA3, and DG depending on the age and sex of the rats. The results obtained suggest that hippocampal aging is related to a decrease in prolactin receptors, which helps to better understand brain aging. Junta de Castilla y León (Spain) eng MDPI Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Hippocampus Short prolactin receptor Large prolactin receptor Aging Hippocampus Aging Receptors, Prolactin receptores de prolactina hipocampo envejecimiento Lifetime variations of prolactin receptor isoforms mRNA in the hippocampus and dentate gyrus of the rat—Effects of aging info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://doi.org/10.3390/ijms26115023 2018/00221/001 International Journal of Molecular Sciences 26 11 5023