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oai:gredos.usal.es:10366/1691122026-01-22T01:03:08Zcom_10366_4613com_10366_4576com_10366_3823col_10366_4615

Valdés Baizabal, Catalina Gutiérrez Parras, Gloria Aguilar Ayala, Yaneri Malmierca, Manuel S. 2026-01-21T09:08:41Z 2026-01-21T09:08:41Z 2017 Valdés-Baizabal, C., Parras, G. G., Ayala, Y. A., y Malmierca, M. S. (2017). Endocannabinoid modulation of stimulus-specific adaptation in inferior colliculus neurons of the rat. Scientific Reports, 7(1), 6997. https://doi.org/10.1038/s41598-017-07460-w http://hdl.handle.net/10366/169112 10.1038/s41598-017-07460-w 2045-2322 [ES] Cannabinoid receptors (CBRs) are widely distributed in the brain, including the inferior colliculus (IC). Here, we aim to study whether endocannabinoids influence a specific type of neuronal adaptation, namely, stimulus-specific adaptation (SSA) found in some IC neurons. SSA is important because it has been found as early as the level of the midbrain and therefore it may be a neuronal correlate of early indices of deviance detection. Furthermore, recent studies have demonstrated a direct link between SSA and MMN, that is widely used as an outcome measure in a variety of human neurodegenerative disorders. SSA is considered a form of short-term plasticity, and CBRs have been shown to play a role in short-term neural plasticity. Therefore, it is reasonable to hypothesize that endocannabinoids may play a role in the generation or modulation of SSA. We recorded single units in the IC under an oddball paradigm stimulation. The results demonstrate that cannabinoid agonists lead to a reduction in the neuronal adaptation. This change is due to a differential increase of the neuronal firing rate to the standard tone alone. Furthermore, we show that the effect is mediated by the cannabinoid receptor 1 (CBR1). Thus, cannabinoid agonists down-modulate SSA in IC neurons. We thank Drs Flora M. Antunes, Edward Bartlett, Nell B. Cant, Daniel Duque, Douglas L. Oliver, Javier Nieto-Diego, David Pérez-González, and Alan R. Palmer for their comments on a previous version of the manuscript and for their constructive criticisms. We also thank Ms. Marianny Janiree Pernía Rosales for helping with the histological section photomicrography. Financial support was provided by the Spanish MINECO (SAF2016-75803-P) and JCYL (SA343U14) to MSM. CVB held a fellowship from the Mexican CONACyT (216652). GGP held a fellowship from the Spanish MINECO (BES-2014-069113) and YAA held fellowships from the Mexican CONACyT (216106) and SEP. applicatio/pdf eng Springer Nature Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Endocannabinoids Stimulus-specific adaptation (SSA) Inferior colliculus CB! receptor (CB1R) Oddball paradigm 2411.11 Neurofisiología 2411.13 Fisiología de la Audición Endocannabinoid Modulation of Stimulus-Specific Adaptation in Inferior Colliculus Neurons of the Rat info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://doi.org/10.1038/s41598-017-07460-w SAF2016-75803-P SA343U14 216652 BES-2014-069113 216106 Scientific Reports 7 1