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oai:gredos.usal.es:10366/1698802026-02-19T01:01:43Zcom_10366_128023com_10366_3947com_10366_3946com_10366_3823col_10366_128025

San Feliciano Martín, Laura Remesal Escalero, Ana Belén Isidoro García, María Ludeña de la Cruz, María Dolores 2026-02-18T13:53:55Z 2026-02-18T13:53:55Z 2011 San Feliciano, L., Remesal, A., Isidoro-García, M., & Ludeña, D. (2011). Dexamethasone and betamethasone for prenatal lung maturation: Differences in vascular endothelial growth factor expression and alveolarization in rats. Neonatology, 100(1), 105-110. https://doi.org/10.1159/000323490 1661-7800 http://hdl.handle.net/10366/169880 10.1159/000323490 1661-7819 [EN]Fetal and postnatal lung development is regulated by glucocorticoids. The use of antenatal corticosteroids is reported to produce effects on vascular endothelial growth factor (VEGF), which plays a crucial role in pulmonary development. Objectives: The purpose of this study was to compare pulmonary VEGF expression in newborn rats that were exposed to antenatal betamethasone versus dexamethasone and to evaluate its impact on the alveolarization period of rats (0–14 days of life). Methods: Betamethasone, dexamethasone or equivalent saline solution (control group) was administered to pregnant rats on 20th and 21st days of gestation. Pulmonary VEGF mRNA, VEGF protein expression, and alveolarization changes were evaluated at birth and at 14 days of life. Results: Betamethasone and dexamethasone were observed to have different actions on VEGF expression with a correlation with alveolarization on both days of study. Antenatal dexamethasone decreased VEGF expression, betamethasone tended to produce the induction of the expression of VEGF, and moreover, betamethasone did not produce a decrease in alveolarization as seen in the animals eng http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/embargoedAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional Antenatal corticosteroids Alveolarization VEGF Dexamethasone and betamethasone for prenatal lung maturation: Differences in vascular endothelial growth factor expression and alveolarization in rats info:eu-repo/semantics/article