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oai:gredos.usal.es:10366/1698832026-02-19T01:01:48Zcom_10366_128023com_10366_3947com_10366_3946com_10366_3823col_10366_128025

Remesal Escalero, Ana Belén Pedraz, Carmen San Feliciano Martín, Laura Ludeña de la Cruz, María Dolores 2026-02-18T14:24:00Z 2026-02-18T14:24:00Z 2009 Remesal, A., Pedraz, C., San Feliciano, L., & Ludeña, D. (2009). Pulmonary expression of vascular endothelial growth factor (VEGF) and alveolar septation in a newborn rat model exposed to acute hypoxia and recovered under conditions of air or hyperoxia. Histology and Histopathology, 24(3), 325-330. 0213-3911 http://hdl.handle.net/10366/169883 10.14670/HH-24.325 [EN]Vascular endothelial growth factor (VEGF) is an endothelial cell growth factor expressed in normal lung tissue. The aim of the study was to investigate the expression of VEGF and its repercussions as regards alveolarization in the developing rat lung. We studied pulmonary VEGF expression at 0 and 14 days of life in Wistar rats. Rat pups were exposed to hypoxia for two hours during the first hours of life and recovered under conditions of hyperoxia or normoxia for a further two hours, or not recovered. The animals of the control group were only exposed to conditions of normoxia. Our results showed that VEGF was increased in the lungs of the animals that were exposed to hypoxia but we did not find any correlation with the septation. The VEGF was decreased in the lungs of animals exposed to hyperoxia after neonatal hypoxia. We observed this at 0 and 14 days of life, and it was correlated with a lower degree of alveolarization at 14 days of life. Our data suggest that hyperoxia after neonatal hypoxia at birth may give rise to a decrease in the expression of VEGF, possibly permanently, together with a reduction in alveolar development. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/embargoedAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional VEGF Hypoxia Hyperoxia Lung development Alveolarization Pulmonary expression of vascular endothelial growth factor (VEGF) and alveolar septation in a newborn rat model exposed to acute hypoxia and recovered under conditions of air or hyperoxia info:eu-repo/semantics/article