2026-09-16T17:19:43Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1710312026-04-18T00:01:20Zcom_10366_4173com_10366_4055com_10366_3946com_10366_3823col_10366_4174

Valero Juan, Margarita Pérez Revuelta, Blanca I. Rodríguez Hernández, Licesio Jesús Naproxen Inclusion complex Polyvinylpyrrolidone Ultraviolet-visible absorption and emission spectroscopy Fourier transform infrared spectroscopy [EN]The aim of this study was to investigate the effects of the presence of the water-soluble polymer polyvinylpyrrolidone K-25 (MW=24,000 g/mol) on the complexation of the AINE naproxen, in its sodium salt form, with the β-cyclodextrin. The data revealed that the polyvinylpyrrolidone K-25 interacts with the drug as well as with the drug:β-cyclodextrin inclusion complex. The polymer shows more affinity for the inclusion complex, K=(6.67±0.292)×10−5 M−1 than for the free drug, (2.08±0.208)×10−5 M−1. The presence of different proportions of polymer, in a range 0–1% (w/w) of polyvinylpyrrolidone, does not increase the ability of drug–cyclodextrin complexation but important changes in the driving force of complex formation were detected, depending on the percentage of polyvinylpyrrolidone K-25 present. At low polymer concentrations, the complexation process is driven entropically, while at higher PVP proportions it is enthalpically favored. In the ternary system, polyvinylpyrrolidone K-25 partially or totally coats the drug:β-cyclodextrin inclusion complex interacting with the β-cyclodextrin (through hydrogen bonds), and with the naproxen. 2026-04-17 2026-04-17 2003 info:eu-repo/semantics/article Valero, M., Pérez-Revuelta, B. I., & Rodríguez, L. J. (2003). Effect of PVP K-25 on the formation of the naproxen:β-ciclodextrin complex. International Journal of Pharmaceutics, 253(1-2), 97-110. https://doi.org/10.1016/S0378-5173(02)00664-6 0378-5173 http://hdl.handle.net/10366/171031 10.1016/S0378-5173(02)00664-6 eng https://doi.org/10.1016/S0378-5173(02)00664-6 http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier