2026-09-14T20:34:01Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1710512026-04-22T00:01:23Zcom_10366_4173com_10366_4055com_10366_3946com_10366_3823col_10366_4174

Valero Juan, Margarita Costa, S.M.B. Ascenso, José R. Velázquez Salicio, María Mercedes Rodríguez Hernández, Licesio Jesús 2026-04-21T07:15:53Z 2026-04-21T07:15:53Z 1999 Valero, M., Costa, S. M. B., Ascenso, J. R., Velázquez, M. M., & Rodríguez, L. J. (1999). Complexation of the non-steroidal anti-inflammatory drug Nabumetone with modified and unmodified cyclodextrins. Journal of Inclusion Phenomena, 35(4), 663-677. https://doi.org/10.1023/A:1008011228459 1388-3127 http://hdl.handle.net/10366/171051 10.1023/A:1008011228459 1573-1111 [EN]The inclusion of the anti-inflammatory drug, Nabumetone, in α-, β-and hydroxypropylβ-cyclodextrin (CDs) is studied using UV-VIS absorption and steady-state fluorescence emission. Binding constants and thermodynamic parameters of complex formation are determined by spectrofluorimetry. The inclusion phenomena of Nabumetone with the three cyclodextrins is compared with that of the well known similar anti-inflammatory drug Naproxen. In the case of Nabumetone pronounced differences are observed in the complexation process with each cyclodextrin whereas the respective Naproxen complexes are nearly identical. 1H-NMR experiments show that the inclusion process in Nabumetone can occur either through the substituents in the -2 (butanone) or -6 (methoxy) positions in the naphthalene ring. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional Nabumetone Naproxen Cyclodextrin UV-absorption spectroscopy Fluorescence spectroscopy Thermodynamics Proton NMR Complexation of the non-steroidal anti-inflammatory drug Nabumetone with modified and unmodified cyclodextrins info:eu-repo/semantics/article