2026-09-15T17:41:45Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/177092025-06-05T12:40:28Zcom_10366_110570com_10366_4576com_10366_3823com_10366_133043com_10366_3966com_10366_3947com_10366_3946col_10366_110571col_10366_135272col_10366_3967

Díaz Hernández, Juan Ignacio Almeida Parra, María Ángeles Delgado Esteban, María Fernández Sánchez, Emilio Bolaños Hernández, Juan Pedro 2009-01-21 2009-10-07T09:10:23Z 2009-10-07T09:10:23Z 2005 Díaz Hernández, J.I., Almeida Parra, A., Delgado Esteban, M., Fernández Sánchez, E., y Bolaños Hernández, J.P. (2005). Knockdown of glutamate-cysteine ligase by small hairpin RNA (shRNA) reveals that both catalytic and modulatory subunits are essential for the survival of primary neurons. "Journal of Biological Chemistry", 280 (47), 38992-39001. http://hdl.handle.net/10366/17709 http://hdl.handle.net/10366/17709 El silenciamiento génico mediante RNAi de cada una de las dos subunidades que conforman la glutamato-cisteína ligasa (enzima limitante de la biosíntesis de glutation) es capaz de inducir apoptosis neuronal por disminución de su capacidad antioxidante. El artículo describe varias secuencias de RNA interferente para cada subunidad de la enzima mencionada. 10 p. application/pdf Inglés eng American Society of Biological Chemists (Bethesda, Estados Unidos) Attribution-NonCommercial-NoDerivs 3.0 Unported https://creativecommons.org/licenses/by-nc-nd/3.0/ info:eu-repo/semantics/openAccess RNA de interferencia Glutamato-cisteina Ligasa Neuronas Apoptosis Óxido nítrico RNAi sirRNA shRNA Glutation Knockdown of glutamate-cysteine ligase by small hairpin RNA (shRNA) reveals that both catalytic and modulatory subunits are essential for the survival of primary neurons info:eu-repo/semantics/article info:eu-repo/semantics/article