2024-03-28T11:52:01Zhttps://gredos.usal.es/oai/requestoai:gredos.usal.es:10366/1407212022-02-07T14:41:03Zcom_10366_4028com_10366_3947com_10366_3946com_10366_3823col_10366_4029
Carro, Lorena
Nouioui, Imen
Sangal, Vartul
Meier-Kolthoff, Jan P.
Trujillo, Martha E.
Montero-Calasanz, Maria del Carmen
Sahin, Nevzat
Smith, Darren Lee
Kim, Kristi E.
Peluso, Paul
Deshpande, Shweta
Woyke, Tanja
Shapiro, Nicole
Kyrpides, Nikos C.
Klenk, Hans-Peter
Göker, Markus
Goodfellow, Michael
2020-01-29T12:09:59Z
2020-01-29T12:09:59Z
2018
Carro, L., Nouioui, I., Sangal, V. et al. (2018). Genome-based classification of micromonosporae with a focus on their biotechnological and ecological potential. Scientific Reports, 8, 525. https://doi.org/10.1038/s41598-017-17392-0
http://hdl.handle.net/10366/140721
10.1038/s41598-017-17392-0
2045-2322
[EN] There is a need to clarify relationships within the actinobacterial genus Micromonospora, the type
genus of the family Micromonosporaceae, given its biotechnological and ecological importance. Here,
draft genomes of 40 Micromonospora type strains and two non-type strains are made available through
the Genomic Encyclopedia of Bacteria and Archaea project and used to generate a phylogenomic
tree which showed they could be assigned to well supported phyletic lines that were not evident in
corresponding trees based on single and concatenated sequences of conserved genes. DNA G+C ratios
derived from genome sequences showed that corresponding data from species descriptions were
imprecise. Emended descriptions include precise base composition data and approximate genome
sizes of the type strains. antiSMASH analyses of the draft genomes show that micromonosporae have
a previously unrealised potential to synthesize novel specialized metabolites. Close to one thousand
biosynthetic gene clusters were detected, including NRPS, PKS, terpenes and siderophores clusters
that were discontinuously distributed thereby opening up the prospect of prioritising gifted strains
for natural product discovery. The distribution of key stress related genes provide an insight into how
micromonosporae adapt to key environmental variables. Genes associated with plant interactions
highlight the potential use of micromonosporae in agriculture and biotechnology.
application/pdf
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
Micromonospora
Microbiología
Genética
Actinobacterial genus
Actinobacteria
Microbiology
3201.03 Microbiología Clínica
2414.04 Bacteriología
Actinobacteria
microbiología
Genome-based classification of micromonosporae with a focus on their biotechnological and ecological potential
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://doi.org/10.1038/s41598-017-17392-0
Scientific Reports
8
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