2024-03-28T12:42:54Zhttps://gredos.usal.es/oai/requestoai:gredos.usal.es:10366/1381412022-02-07T15:34:02Zcom_10366_135255com_10366_4512com_10366_3823col_10366_135256
Low-count monoclonal B-cell lymphocytosis persists after seven years of follow up and is associated with a poorer outcome
Criado García, Ignacio
Rodríguez Caballero, Arancha
Gutiérrez Troncoso, María Laura
Pedreira, Carlos
Alcoceba Sánchez, Miguel
Nieto Pérez, Wendy Grey
Teodosio, Cristina
Bárcena Carrasco, Paloma
Romero, Alfonso
Fernández Navarro, Paulino
González Díaz, Marcos
Almeida Parra, Julia María
Orfao de Matos Correia e Vale, José Alberto
MBL
Haematology
[EN]Low-count monoclonal B-cell lymphocytosis is defined by the presence
of very low numbers of circulating clonal B cells, usually phenotypically
similar to chronic lymphocytic leukemia cells, whose
biological and clinical significance remains elusive. Herein, we re-evaluated
65/91 low-count monoclonal B-cell lymphocytosis cases (54 chronic
lymphocytic leukemia-like and 11 non-chronic lymphocytic leukemialike)
followed-up for a median of seven years, using high-sensitivity
flow cytometry and interphase fluorescence in situ hybridization.
Overall, the clone size significantly increased in 69% of low-count monoclonal
B-cell lymphocytosis cases, but only one subject progressed to
high-count monoclonal B-cell lymphocytosis. In parallel, the frequency
of cytogenetic alterations increased over time (32% vs. 61% of cases,
respectively). The absolute number of the major T-cell and natural killer
cell populations also increased, but only among chronic lymphocytic
leukemia-like cases with increased clone size vs. age- and sex-matched
controls. Although progression to chronic lymphocytic leukemia was
not observed, the overall survival of low-count monoclonal B-cell lymphocytosis
individuals was significantly reduced vs. non-monoclonal Bcell
lymphocytosis controls (P=0.03) plus the general population from
the same region (P≤0.001), particularly among females (P=0.01); infection
and cancer were the main causes of death in low-count monoclonal
B-cell lymphocytosis. In summary, despite the fact that mid-term progression
from low-count monoclonal B-cell lymphocytosis to high-count
monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia
appears to be unlikely, these clones persist at increased numbers, usually
carrying more genetic alterations, and might thus be a marker of an
impaired immune system indirectly associated with a poorer outcome,
particularly among females.
2018-07-31T09:00:43Z
2018-07-31T09:00:43Z
2018-07
info:eu-repo/semantics/article
Haematologica 2018 Volume 103(7):1198-1208
0390-6078
1592-8721
http://hdl.handle.net/10366/138141
doi:10.3324/haematol.2017.183954
eng
https://doi.org/10.3324/haematol.2017.183954
RD06/0020/0035-FEDER y RD12/0036/0048-FEDER
CB16/12/00400-FEDER
FIS PI06/0824-FEDER, PS09/02430-FEDER, PI12/00905- FEDER, PI16/00787-FEDER and PI17/00399-FEDER
SAN/1778/2009
TA2014-09963
Attribution-NonCommercial-NoDerivs 3.0 Unported
https://creativecommons.org/licenses/by-nc-nd/3.0/
info:eu-repo/semantics/openAccess
application/pdf
European Hematology Association (La Haya, Países Bajos)
https://gredos.usal.es/bitstream/10366/138141/3/Criado_et_al_HAEMATOLOGICA_2018.pdf.jpg
Hispana
TEXT
https://creativecommons.org/licenses/by-nc-nd/3.0/
Gredos. Repositorio Documental de la Universidad de Salamanca
http://hdl.handle.net/10366/138141