TY  - JOUR 
AU  - Vicente-Blázquez, Alba
AU  - González, Myriam
AU  - Medarde Agustín, Manuel
AU  - Mollinedo, Faustino
AU  - Peláez, Rafael
PY  - 2021
SN  - 1475-6366
UR  - http://hdl.handle.net/10366/148380
AB  - Searching for improved indolesulfonamides with higher polarities, 45 new analogues with modifications on the sulfonamide nitrogen, the methoxyaniline, and/or the indole 3-position were synthesised. They show submicromolar to nanomolar...
LA  - eng
KW  - Design
KW  - Synthesis
KW  - Indolesulfonamides
KW  - antimitotic
KW  - colchicine-site
KW  - structure–activity relationships
KW  - total polar surface area
TI  - New indolesulfonamide derivatives targeting the colchicine site of tubulin: synthesis, anti-tumour activity, structure–activity relationships, and molecular modelling
DO  - 10.1080/14756366.2021.1975277
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
VL  - 36
M2  - 2025
ER  -