TY  - JOUR 
AU  - González Díaz, Myriam
AU  - Ellahioui, Younes
AU  - Álvarez Lozano, Raquel
AU  - Gallego-Yerga, Laura
AU  - Caballero Salvador, Esther
AU  - Vicente Blázquez, Alba
AU  - Ramudo González, Laura
AU  - Marín, Miguel
AU  - Sanz, Cristina
AU  - Medarde Agustín, Manuel
AU  - Peláez Lamamie de C. Arroyo, Rafael
PY  - 2019
UR  - http://hdl.handle.net/10366/148389
AB  - Colchicine site ligands suffer from low aqueous solubility due to the highly hydrophobic nature of the binding site. A new strategy for increasing molecular polarity without exposing polar groups—termed masked polar group incorporation (MPGI)—was...
LA  - eng
KW  - Tubulin
KW  - Colchicine-site
KW  - Combretastatins
KW  - Isocombretastatins
KW  - Phenstatins
KW  - Nitrogenated
KW  - Masked polar group introduction
KW  - Solubility
KW  - Cytotoxicity
KW  - Docking
TI  - The Masked Polar Group Incorporation (MPGI) Strategy in Drug Design: Effects of Nitrogen Substitutions on Combretastatin and Isocombretastatin Tubulin Inhibitors
DO  - 10.3390/molecules24234319
T2  - Molecules
VL  - 24
M2  - 4319
ER  -