TY - JOUR AU - Mateos Manteca, María Victoria AU - Hernández, Miguel-Teodoro AU - Giraldo, Pilar AU - De la Rubia, Javier AU - De Arriba, Felipe AU - López Corral, Lucía AU - Rosiñol, Laura AU - Paiva, Bruno AU - Palomera, Luis AU - Bargay, Joan AU - Oriol, Albert AU - Prósper, Felipe AU - López, Javier AU - Olavarría, Eduardo AU - Quintana, Nuria AU - García, José-Luis AU - Bladé, Joan AU - Lahuerta, Juan José AU - San Miguel Izquierdo, Jesús Fernando PY - 2013 UR - http://hdl.handle.net/10366/154298 AB - [EN]For patients with smoldering multiple myeloma, the standard of care is observation until symptoms develop. However, this approach does not identify high-risk patients who may benefit from early intervention. In this randomized, open-label, phase... LA - eng PB - NEJM Group KW - Adult KW - Aged KW - Aged, 80 and over KW - Antineoplastic Combined Chemotherapy Protocols KW - Dexamethasone KW - Disease Progression KW - Female KW - Follow-Up Studies KW - Humans KW - Induction Chemotherapy KW - Lenalidomide KW - Male KW - Middle Aged KW - Multiple Myeloma KW - Risk KW - Survival Rate KW - Thalidomide KW - Disease Progression KW - Aged KW - Adult KW - Induction Chemotherapy KW - Follow-Up Studies KW - Humans KW - Antineoplastic Combined Chemotherapy Protocols KW - Middle Aged KW - Multiple Myeloma KW - Risk KW - Thalidomide KW - Dexamethasone KW - Survival Rate TI - Lenalidomide plus dexamethasone for high-risk smoldering multiple myeloma DO - 10.1056/NEJMoa1300439 T2 - The New England journal of medicine VL - 369 M2 - 438 ER -