TY - JOUR AU - Misiewicz-Krzeminska, Irena AU - Alonso Sarasquete, María Eugenia AU - Salim Quwaider, Dalia AU - Krzeminski, Patryk AU - Ticona, Fany V AU - Paíno Gómez, María Teresa AU - Delgado, Manuel AU - Aires, Andreia AU - Ocio San Miguel, Enrique M. AU - García Sanz, Ramón AU - San Miguel Izquierdo, Jesús Fernando AU - Gutiérrez Gutiérrez, Norma Carmen PY - 2013 SN - 0390-6078 UR - http://hdl.handle.net/10366/154958 AB - [EN]MicroRNA have been demonstrated to be deregulated in multiple myeloma. We have previously reported that miR-214 is down-regulated in multiple myeloma compared to in normal plasma cells. The functional role of miR-214 in myeloma pathogenesis was... LA - eng PB - Ferrata Storti Foundation KW - Myeloma KW - MicroRNA-214 KW - p53 KW - DNA replication KW - Reverse Transcriptase Polymerase Chain Reaction KW - Cyclin-Dependent Kinase Inhibitor p21 KW - DNA Methylation KW - Immunoblotting KW - Cell Cycle KW - Gene Expression Regulation KW - Humans KW - Proto-Oncogene Proteins KW - Cell Line KW - Oligonucleotide Array Sequence Analysis KW - Proteasome Endopeptidase Complex KW - Cell Proliferation KW - DNA Replication KW - Multiple Myeloma KW - MicroRNAs KW - Apoptosis KW - Gene Expression Profiling KW - Tumor Suppressor Protein p53 KW - bcl-2-Associated X Protein KW - Cell Cycle Proteins TI - Restoration of microRNA-214 expression reduces growth of myeloma cells through positive regulation of P53 and inhibition of DNA replication DO - 10.3324/haematol.2012.070011 T2 - Haematologica VL - 98 M2 - 640 ER -