TY  - JOUR 
AU  - Corraliza-Gomez, Miriam
AU  - Bermejo, Teresa
AU  - Lilue, Jingtao
AU  - Rodríguez-Iglesias, Noelia
AU  - Valero , Jorge
AU  - Cozar-Castellano, Irene
AU  - Arranz, Eduardo
AU  - Sánchez, Diego
AU  - Ganfornina, Maria Dolores
PY  - 2023
UR  - http://hdl.handle.net/10366/154979
AB  - The insulin-degrading enzyme (IDE) is an evolutionarily conserved zinc-dependent metallopeptidase highly expressed in the brain, where its specific functions remain poorly understood. Besides insulin, IDE is able to cleave many substrates in vitro,...
LA  - eng
KW  - Amyloid-beta endocytosis
KW  - Cytokine secretion
KW  - Inflammation
KW  - Insulin-degrading enzyme
KW  - Microglia
KW  - Microglial proliferation
KW  - Myelin phagocytosis
KW  - Oxidative stress
KW  - Inflammation
KW  - Cytokines
KW  - Endocytosis
KW  - Alzheimer Disease
KW  - Phagocytosis
KW  - Oxidative Stress
TI  - Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer’s disease and brain aging
DO  - 10.1186/s12974-023-02914-7
T2  - Journal of Neuroinflammation
VL  - 20
ER  -