TY  - JOUR 
AU  - Soldati, Chiara
AU  - López Fabuel, Irene
AU  - Wanderlingh, Luca G
AU  - García Macia, Marina
AU  - Monfregola, Jlenia
AU  - Esposito, Alessandra
AU  - Napolitano, Gennaro
AU  - Guevara-Ferrer, Marta
AU  - Scotto Rosato, Anna
AU  - Krogsaeter, Einar K
AU  - Paquet, Dominik
AU  - Grimm, Christian M.
AU  - Montefusco, Sandro
AU  - Braulke, Thomas
AU  - Storch, Stephan
AU  - Mole, Sara E
AU  - De Matteis, Maria A
AU  - Ballabio, Andrea
AU  - Sampaio, Julio L
AU  - McKay, Tristan R
AU  - Johannes, Ludger
AU  - Bolaños Hernández, Juan Pedro
AU  - Medina, Diego L.
PY  - 2021
SN  - 1757-4676
UR  - http://hdl.handle.net/10366/155194
AB  - [EN]Batten diseases (BDs) are a group of lysosomal storage disorders characterized by seizure, visual loss, and cognitive and motor deterioration. We discovered increased levels of globotriaosylceramide (Gb3) in cellular and murine models of CLN3 and...
LA  - eng
PB  - Wiley
KW  - CLN3
KW  - CLN7
KW  - High content imaging screening
KW  - Tamoxifen
KW  - TFEB
KW  - Phenotype
KW  - Membrane Glycoproteins
KW  - Neuronal Ceroid-Lipofuscinoses
KW  - Tamoxifen
KW  - Animals
KW  - Humans
KW  - Molecular Chaperones
KW  - Drug Repositioning
KW  - Lysosomes
KW  - Mice
TI  - Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype
DO  - 10.15252/emmm.202013742
T2  - EMBO molecular medicine
VL  - 13
M2  - e13742
ER  -