TY - JOUR AU - Chamorro-Jorganes, Aranzazu AU - Grande, Maria Teresa AU - Herranz, Beatriz AU - Jerkic, Mirjana AU - Griera, Mercedes AU - González Núñez, María AU - Santos de Dios, Eugenio Miguel AU - Rodríguez-Puyol, Diego AU - López-Novoa, José Miguel AU - Rodriguez-Puyol, Manuel PY - 2010 SN - 0194-911X UR - http://hdl.handle.net/10366/155341 AB - [EN]The aim of the present experiments was to evaluate the differences in arterial pressure between H-Ras lacking mice and control mice and to analyze the mechanisms involved in the genesis of the differences. H-Ras lacking mice and mouse embryonic... LA - eng PB - Lippincott Williams & Wilkins KW - Arterial pressure KW - cGMP-dependent protein kinase KW - Cyclic GMP KW - H-Ras protein KW - Nitric oxide KW - Soluble guanylyl cyclase KW - Aorta KW - Fibroblasts KW - Cells KW - Nitric Oxide KW - Statistics KW - Blood Pressure KW - Cyclic GMP KW - Hypotension KW - Cyclic GMP-Dependent Protein Kinases KW - Guanylate Cyclase KW - Phosphorylation KW - Nitric Oxide Synthase Type III KW - Immunohistochemistry KW - Animals KW - Signal Transduction KW - Up-Regulation KW - ras Proteins KW - Mice TI - Targeted genomic disruption of h-ras induces hypotension through a NO-cGMP-PKG pathway-dependent mechanism DO - 10.1161/HYPERTENSIONAHA.110.152587 T2 - Hypertension (Dallas, Tex. : 1979) VL - 56 M2 - 484 ER -