TY - JOUR AU - Roccaro, Aldo M AU - Sacco, Antonio AU - Jiménez, Cristina AU - Maiso, Patricia AU - Moschetta, Michele AU - Mishima, Yuji AU - Aljawai, Yosra AU - Sahin, Ilyas AU - Kuhne, Michelle AU - Cardarelli, Pina AU - Cohen, Lewis AU - San Miguel Izquierdo, Jesús Fernando AU - García Sanz, Ramón AU - Ghobrial, Irene M PY - 2014 SN - 0006-4971 UR - http://hdl.handle.net/10366/155409 AB - [EN]The C-X-C chemokine receptor type 4 (CXCR4) plays a crucial role in modulating cell trafficking in hematopoietic stem cells and clonal B cells. We screened 418 patients with B-cell lymphoproliferative disorders and described the presence of the... LA - eng PB - American Society of Hematology KW - Waldenstrom macrogobulinemia KW - Management KW - Treatment KW - C1013G/CXCR4 KW - Disease-Free Survival KW - Transplantation KW - Boronic Acids KW - Heterografts KW - Hematopoietic Stem Cell Transplantation KW - Humans KW - Pyrazines KW - Drug Therapy KW - Cell Proliferation KW - Waldenstrom Macroglobulinemia KW - Neoplasm Transplantation KW - Drug Resistance KW - Enzyme Inhibitors KW - Mutation KW - Neoplasm Metastasis KW - Antibodies KW - Thalidomide KW - Animals KW - Survival Rate KW - Mice TI - C1013G/CXCR4 acts as a driver mutation of tumor progression and modulator of drug resistance in lymphoplasmacytic lymphoma DO - 10.1182/blood-2014-03-564583 T2 - Blood VL - 123 M2 - 4120 ER -