TY - JOUR AU - Boada-Romero, Emilio AU - Serramito Gómez, Inmaculada AU - Sacristán Martín, María Paz AU - Boone, David L. AU - Xavier, Ramnik J. AU - Pimentel Muiños, Felipe Xosé PY - 2016 UR - http://hdl.handle.net/10366/155918 AB - [EN]A coding polymorphism of human ATG16L1 (rs2241880; T300A) increases the risk of Crohn’s disease and it has been shown to enhance susceptibility of ATG16L1 to caspase cleavage. Here we show that T300A also alters the ability of the C-terminal... LA - eng PB - Nature Research KW - Autophagy KW - Crohn Disease TI - The T300A Crohn’s disease risk polymorphism impairs function of the WD40 domain of ATG16L1 DO - 10.1038/ncomms11821 T2 - Nature Communications VL - 7 M2 - 1 ER -