TY  - JOUR 
AU  - Quijada Álamo, Miguel
AU  - Hernández Sánchez, María
AU  - Alonso-Pérez, Verónica
AU  - Rodríguez Vicente, Ana E.
AU  - García-Tuñón, Ignacio
AU  - Martín Izquierdo, Marta
AU  - Hernández Sánchez, Jesús María
AU  - Herrero Hernández, Ana Belén
AU  - Bastida Bermejo, José María
AU  - San Segundo, Laura
AU  - Gruber, Michaela
AU  - García Hernández, Juan Luis
AU  - Yin, Shanye
AU  - Ten Hacken, Elisa
AU  - Benito Sánchez, Rocío
AU  - Ordóñez García, José Luis
AU  - Wu, Catherine J.
AU  - Hernández Rivas, Jesús María
PY  - 2020
SN  - 0887-6924
UR  - http://hdl.handle.net/10366/158975
AB  - [EN]The deletion of 11q (del(11q)) invariably comprises ATM gene in chronic lymphocytic leukemia (CLL). Concomitant mutations in this gene in the remaining allele have been identified in 1/3 of CLL cases harboring del(11q), being the biallelic loss of...
LA  - eng
PB  - SPRINGER NATURE
KW  - CRISPR
KW  - CLL
KW  - BCR inhibition
KW  - PARP inhibition
KW  - Chronic lymphocytic leukemia
KW  - Leukemia, B-Cell
KW  - Leukemia
KW  - CRISPR-Cas Systems
TI  - CRISPR/Cas9-generated models uncover therapeutic vulnerabilities of del(11q) CLL cells to dual BCR and PARP inhibition
DO  - 10.1038/S41375-020-0714-3
T2  - Leukemia
VL  - 34
M2  - 1599
ER  -