TY - JOUR AU - Davies, Andrea AU - Rodríguez Vicente, Ana E. AU - Austin, Gemma AU - Loaiza, Sandra AU - Foroni, Letizia AU - Clark, Richard E AU - Pirmohamed, Munir PY - 2020 UR - http://hdl.handle.net/10366/162290 AB - [EN]Tyrosine kinase inhibitors (TKIs), the treatment of choice for chronic myeloid leukaemia (CML), can cause lower gastrointestinal (GI) toxicity which is manifested as diarrhoea. The mechanisms are not fully understood. The enteroendocrine... LA - eng KW - Leucemia mieloide crónica KW - Polimorfismos KW - Farmacogenética KW - Imatinib KW - Aged KW - Young Adult KW - Leukemia KW - Adult KW - Diarrhea KW - Gene Frequency KW - Humans KW - Serotonin Plasma Membrane Transport Proteins KW - Adolescent KW - Minisatellite Repeats KW - Antineoplastic Agents KW - Middle Aged TI - Serotonin re-uptake transporter gene polymorphisms are associated with imatinib-induced diarrhoea in chronic myeloid leukaemia patients DO - 10.1038/s41598-020-65350-0 T2 - Scientific Reports VL - 10 M2 - 8394 ER -