TY  - THES 
A3  - García Bustelo, Xosé Ramón
AU  - Rojas de Pablo, Isabel de
PY  - 2024
UR  - http://hdl.handle.net/10366/163651
AB  - [EN]VAV1 is a RHO guanine nucleotide exchange factor (GEF) predominantly expressed in hematopoietic cells, where it activates RHO GTPases —primarily RAC1—and plays essential roles in T cell development, immune response and cell signaling. Recent...
LA  - eng
KW  - Tesis y disertaciones académicas
KW  - Universidad de Salamanca (España)
KW  - Tesis Doctoral
KW  - Academic dissertations
KW  - Proteínas VAV
KW  - Oncología
KW  - VAV proteins
KW  - Oncology
KW  - Inhibidores
KW  - Inhibitors
KW  - Drug Design
KW  - Proto-Oncogene Proteins c-vav
KW  - Guanine Nucleotide Dissociation Inhibitors
TI  - VAV1 inhibition: exploring drug design strategies for targeting gef activity
M3  - info:eu-repo/semantics/doctoralThesis
ER  -