TY  - JOUR 
AU  - Covarrubias, Anthony J
AU  - Kale, Abhijit
AU  - Perrone, Rosalba
AU  - López Domínguez, José Alberto
AU  - Pisco, Angela Oliveira
AU  - Kasler, Herbert G
AU  - Schmidt, Mark S
AU  - Heckenbach, Indra
AU  - Kwok, Ryan
AU  - Wiley, Christopher D
AU  - Wong, Hoi-Shan
AU  - Gibbs, Eddy
AU  - Iyer, Shankar S
AU  - Basisty, Nathan
AU  - Wu, Qiuxia
AU  - Kim, Ik-Jung
AU  - Silva, Elena
AU  - Vitangcol, Kaitlyn
AU  - Shin, Kyong-Oh
AU  - Lee, Yong-Moon
AU  - Riley, Rebeccah
AU  - Ben-Sahra, Issam
AU  - Ott, Melanie
AU  - Schilling, Birgit
AU  - Scheibye-Knudsen, Morten
AU  - Ishihara, Katsuhiko
AU  - Quake, Stephen R
AU  - Newman, John
AU  - Brenner, Charles
AU  - Campisi, Judith
AU  - Verdin, Eric
PY  - 2020
UR  - http://hdl.handle.net/10366/166750
AB  - [EN]Declining tissue nicotinamide adenine dinucleotide (NAD) levels are linked to ageing and its associated diseases. However, the mechanism for this decline is unclear. Here, we show that pro-inflammatory M1-like macrophages, but not naive or M2...
LA  - eng
KW  - Cellular senescence
KW  - Macrophages
KW  - Aging
KW  - SASP
KW  - NAD
TI  - Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.
DO  - 10.1038/s42255-020-00305-3
T2  - Nature metabolism
VL  - 2
M2  - 1265
ER  -