TY  - JOUR 
AU  - Burrell, Anika L
AU  - Nie, Chuankai
AU  - Said, Meerit
AU  - Simonet, Jacqueline C
AU  - Fernández Justel, David
AU  - Johnson, Matthew C
AU  - Quispe, Joel
AU  - Martínez Buey, Rubén
AU  - Peterson, Jeffrey R
AU  - Kollman, Justin M
AU  - Burrell, Anika L.
AU  - Simonet, Jacqueline C.
AU  - Johnson, Matthew C.
AU  - Buey, Rubén M.
AU  - Peterson, Jeffrey R.
AU  - Kollman, Justin M.
PY  - 2022
SN  - 1545-9993
UR  - http://hdl.handle.net/10366/168989
AB  - [EN]Inosine-5'-monophosphate dehydrogenase (IMPDH), a key regulatory enzyme in purine nucleotide biosynthesis, dynamically assembles filaments in response to changes in metabolic demand. Humans have two isoforms: IMPDH2 filaments reduce sensitivity to...
LA  - eng
KW  - IMP dehydrogenase
KW  - retina
KW  - Nucleotide metabolism
KW  - Allosteric regulation
KW  - Guanosine Triphosphate
KW  - Allosteric Regulation
KW  - Retinal Diseases
KW  - IMP Dehydrogenase
TI  - IMPDH1 retinal variants control filament architecture to tune allosteric regulation
DO  - 10.1038/s41594-021-00706-2
T2  - Nature Structural & Molecular Biology
VL  - 29
M2  - 47
ER  -