TY  - JOUR 
AU  - Plana-Bonamaisó, Anna
AU  - López-Begines, Santiago
AU  - Fernández-Justel, David
AU  - Junza, Alexandra
AU  - Soler-Tapia, Ariadna
AU  - Andilla, Jordi
AU  - Loza-Alvarez, Pablo
AU  - Rosa, Jose Luis
AU  - Miralles, Esther
AU  - Casals, Isidre
AU  - Yanes, Oscar
AU  - de la Villa, Pedro
AU  - Martínez Buey, Rubén
AU  - Méndez, Ana
PY  - 2020
UR  - http://hdl.handle.net/10366/169005
AB  - [EN]We report the in vivo regulation of Inosine-5´-monophosphate dehydrogenase 1 (IMPDH1) in the retina. IMPDH1 catalyzes the rate-limiting step in the de novo synthesis of guanine nucleotides, impacting the cellular pools of GMP, GDP and GTP. Guanine...
LA  - eng
KW  - Retinal metabolism
KW  - Protein phosphorylation
KW  - Enzyme regulation
KW  - Retinitis pigmentosa
KW  - Nucleotide metabolism
KW  - Retina
KW  - Homeostasis
KW  - Biochemical Phenomena
KW  - Gene Expression Regulation
KW  - Adenosine Triphosphate
KW  - IMP Dehydrogenase
KW  - Light
KW  - Photic Stimulation
KW  - Photoreceptor Cells
KW  - Mutation
KW  - Phosphorylation
KW  - Guanosine Triphosphate
KW  - Animals
KW  - Mice
TI  - Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions
DO  - 10.7554/eLife.56418
T2  - eLife
VL  - 9
M2  - e56418
ER  -