TY - JOUR AU - Blázquez Medela, Ana M. AU - García Sánchez, Omar AU - Blanco Gozalo, Víctor AU - Quirós Luis, Yaremi AU - Montero Gómez, María Josefa AU - Martínez Salgado, José Carlos AU - López-Novoa, José M. AU - López Hernández, Francisco José PY - 2014 UR - http://hdl.handle.net/10366/169129 AB - [EN]Hypertension and diabetes are the two leading causes of chronic kidney disease (CKD) eventually leading to end stage renal disease (ESRD) and the need of renal replacement therapy. Mortality among CKD and ESRD patients is high, mostly due to... LA - eng PB - Public Library of Science KW - Hypertension KW - NGAL KW - Urinary Excretion KW - Rats KW - Renal tubular alteration KW - Hyperglycemia KW - NG-Nitroarginine Methyl Ester KW - Perfusion KW - Kidney Tubules KW - Acute-Phase Proteins KW - Diabetes Mellitus KW - Rats KW - Animals KW - Hyperglycemia KW - Hypertension KW - Lipocalins KW - Blood Pressure TI - Hypertension and hyperglycemia synergize to cause incipient renal tubular alterations resulting in increased NGAL urinary excretion in rats DO - 10.1371/journal.pone.0105988 T2 - PLOS ONE VL - 9 M2 - e105988 ER -