TY  - JOUR 
AU  - Gerboth, S.
AU  - Frittoli, E.
AU  - Palamiessi, A.
AU  - Baltanas, F. C.
AU  - Salek, M.
AU  - Rappsilber, J.
AU  - Giuliani, C.
AU  - Troglio, F.
AU  - Rolland, Y.
AU  - Pruneri, G.
AU  - Kreutmair, S.
AU  - Pallavicini, I.
AU  - Zobel, M.
AU  - Cinquanta, M.
AU  - Minucci, S.
AU  - Gómez Rodríguez, Carmela
AU  - Santos de Dios, Eugenio Miguel
AU  - Illert, A. L.
AU  - Scita, G.
PY  - 2017
SN  - 0887-6924
UR  - http://hdl.handle.net/10366/169720
AB  - [EN]Son of Sevenless 1 (SOS1) is a dual guanine nucleotide exchange factor (GEF) that activates the small GTPases RAC and RAS. Although the molecular mechanisms of RAS GEF catalysis have been unveiled, how SOS1 acquires RAC GEF activity and what is...
LA  - eng
PB  - Springer Nature
KW  - SOS1
KW  - CML
KW  - BCR-ABL
TI  - Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis
DO  - 10.1038/leu.2017.267
T2  - Leukemia
VL  - 32
M2  - 820
ER  -