TY  - JOUR 
AU  - Chen, Xi
AU  - Díaz Rodríguez, María Elena
AU  - Ocio San Miguel, Enrique M.
AU  - Paiva, Bruno
AU  - Mortensen, Deborah S.
AU  - López Girona, Antonia
AU  - Chopra, Rajesh
AU  - San Miguel, Jesús
AU  - Pandiella Alonso, Atanasio
PY  - 2014
UR  - http://hdl.handle.net/10366/170912
AB  - The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates cell growth, proliferation, metabolism, and cell survival, and plays those roles by forming two functionally distinct multiprotein complexes: mTOR complex 1 (mTORC1)...
LA  - eng
KW  - Multiple myeloma
KW  - mTOR
KW  - Antimyeloma therapy
KW  - Stromal Cells
KW  - HEK293 Cells
KW  - Humans
KW  - Multiprotein Complexes
KW  - Pyrazines
KW  - TOR Serine-Threonine Kinases
KW  - Cell Line
KW  - Cell Proliferation
KW  - Sirolimus
KW  - Cell Cycle Checkpoints
KW  - Multiple Myeloma
KW  - Cell Survival
KW  - Apoptosis
KW  - Coculture Techniques
KW  - Imidazoles
KW  - Signal Transduction
KW  - RNA Interference
TI  - Genetic and pharmacologic evidence that mTOR targeting outweighs mTORC1 inhibition as an antimyeloma strategy
DO  - 10.1158/1535-7163.MCT-13-0022
T2  - Molecular Cancer Therapeutics
VL  - 13
M2  - 504
ER  -