TY  - JOUR 
AU  - Marin Quilez, Ana
AU  - García-Tuñón, Ignacio
AU  - Benito Sánchez, Rocío
AU  - Ordóñez García, José Luis
AU  - Díaz-Ajenjo, Lorena
AU  - Lama-Villanueva, Ana
AU  - Guerrero Arroyo, María Carmen
AU  - Pérez Losada, Jesús
AU  - González-Porras, José Ramón
AU  - Hernández Rivas, Jesús María
AU  - Del Rey, Mónica
AU  - Bastida Bermejo, José María
PY  - 2025
UR  - http://hdl.handle.net/10366/171556
AB  - [EN]Germline heterozygous variants in RUNX1 lead to Familial Platelet Disorder with Myeloid Leukemia Predisposition (FPD/AML). Cellular and/or animal models are helpful to uncovering the role of a variant in disease progression. Twenty-five mice per...
LA  - eng
PB  - MDPI
KW  - Core Binding Factor Alpha 2 Subunit
KW  - CRISPR-Cas Systems
KW  - Leukemia, Myeloid, Acute
KW  - Blood Platelet Disorders
KW  - Animals
KW  - Mice
KW  - Disease Models, Animal
KW  - Gene Knock-In Techniques
KW  - Phenotype
KW  - Male
KW  - Homozygote
KW  - Phenotype
KW  - Leukemia
KW  - CRISPR-Cas Systems
KW  - Animals
KW  - Blood Platelet Disorders
KW  - Gene Knock-In Techniques
KW  - Homozygote
KW  - Core Binding Factor Alpha 2 Subunit
KW  - Mice
TI  - Examining the Effects of the RUNX1 p.Leu43Ser Variant on FPD/AML Phenotypes Using a CRISPR/Cas9-Generated Knock-In Murine Model
DO  - 10.3390/biom15050708
T2  - Biomolecules
VL  - 15
ER  -