http://hdl.handle.net/10366/4075 Mon, 14 Sep 2026 05:51:30 GMT 2026-09-14T05:51:30Z http://hdl.handle.net/10366/172744 [EN]Spatial transferability remains a major limitation in erosion modelling across environmentally heterogeneous catchments. This study evaluated climatic, vegetation, and morphometric predictors and compared a linear model, Extreme Gradient Boosting (XGBoost), and a hybrid stacking ensemble using 93 catchment–year records from three semi-arid Mediterranean catchments in southern Spain. The methodological contribution lies in jointly evaluating hierarchical variance partitioning and targeted predictor interactions, comparing the linear and XGBoost models under leave-one-catchment-out (LOCO) validation, and examining an internally fitted stacking ensemble based on pooled LOCO base-model predictions. Precipitation was the strongest statistical predictor of the Universal Soil Loss Equation (USLE)-derived annual erosion estimates. Targeted linear interactions did not consistently improve LOCO performance, and the estimated catchment-level variance approached zero after inclusion of the environmental predictors. Under pooled LOCO validation, the linear model yielded a squared Pearson correlation of 0.39, and root mean square error (RMSE) of 47.9 t ha−1 yr−1. XGBoost reduced RMSE to 27.9 t ha−1 yr−1, while the squared correlation was 0.35. he internally fitted stacking meta-model yielded an apparent RMSE of 23.6 t ha−1 yr−1 and a squared correlation of 0.53 on the same pooled predictions used for meta-model estimation. Transferability was catchment-dependent and poorest for Casasola. Because the response was model-derived, only three catchments were available, and the meta-learner lacked an outer spatial validation layer, the stacking results represent an internal comparison rather than definitive evidence of regional transferability. Lower prediction error did not necessarily imply broader spatial generalization or improved process understanding. Thu, 10 Sep 2026 00:00:00 GMT http://hdl.handle.net/10366/172744 2026-09-10T00:00:00Z http://hdl.handle.net/10366/172742 [EN]Background: The clinical utility of the Montreal Cognitive Assessment (MoCA) is often limited by normative data derived from linear models, which do not adequately capture non-linear agerelated decline and score distribution issues like ceiling effects. This study aimed to generate methodologically rigorous normative data for the Spanish MoCA version 8.1 and its Memory Index Score (MIS) using an advanced regression approach. Methods: A total of 2,034 community-dwelling adults (18-89 years; 56.3% women) were assessed. Bayesian beta generalized additive models (GAMs) were used to model the effects of age, sex, and education. Normative data were generated as percentiles from the model's standardized residuals. To facilitate direct clinical application, a user-friendly automated calculator was also developed. Results: Non-linear GAMs demonstrated superior fit and predictive accuracy versus linear models, multiple fractional polynomial (MFP) models, and generalized additive models for location, scale, and shape (GAMLSS). Gains over GAMLSS were small but consistent, and model diagnostics supported the stability of the final solutions. The final models explained a significant amount of variance (Bayesian R² ≈ 0.43 for the MoCA; ≈ 0.26 for the MIS). Age (with a marked nonlinear effect) and education were associated with both outcomes, whereas sex-related effects differed between the MoCA and MIS models. Conclusions: This study provides updated and rigorous normative data for the Spanish MoCA 8.1 and MIS. By accurately modelling demographic effects, the proposed norms and accompanying calculator may support more precise normative interpretation in Spanish adults; however, external clinimetric validation is required before advocating diagnostic use or broad generalization. Fri, 14 Aug 2026 00:00:00 GMT http://hdl.handle.net/10366/172742 2026-08-14T00:00:00Z http://hdl.handle.net/10366/172696 [EN]Research on gender in prehistoric Iberia has focused largely on cemeteries with rich grave goods, while regions with sparse, atypical mortuary records remain understudied. We address this gap for the Middle–Late Bronze Age Cogotas I group (circa 1850–1150 cal BC) by testing whether lateralized burial position (left/right decubitus) expresses gendered norms once sex and age are known. We analysed 29 primary inhumations (13 males/16 females) from 15 sites in the northern Iberian sub-Plateau (Duero basin). Biological sex was assessed osteologically, in 23 cases by enamel peptide proteomics (AMELX/AMELY) and also using the available aDNA; age-atdeath followed standard osteological criteria. We evaluated associations among sex, age, decubitus, deposit type and geography using statistical tests appropriate for small samples, complemented by exploratory multivariate analyses to visualize overall structure. The primary hypothesis was not supported: in the sample, sex and lateral decubitus were not associated, and neither regional quadrants nor logistic models yielded significant results. Age, however, modulated practices. Very young children occurred only in individual burials, whereas older children and adolescents were more frequent in multiple deposits. Sub-regional tendencies were qualitative rather than confirmatory: FR/ML in Western and Eastern versus FL/MR around the middle Douro/Duero basin. Multivariate plots suggested that infants cluster with female and right decubitus, adolescents with male and left, and adults at the opposite axis end, trends to be treated cautiously given small cell counts. It can be concluded that Cogotas I mortuary behaviour lacked a single rigid, gender-coded rule. Instead, gendered performances, that intersected with age, varied according to the territorial context, with the youngest children and some aged women standing outside normal patterns. This integrated osteological–proteomic–statistical approach, to combine with the ‘gender effects’, it will allow to refine social inferences where grave goods are minimal. Thu, 01 Jan 2026 00:00:00 GMT http://hdl.handle.net/10366/172696 2026-01-01T00:00:00Z http://hdl.handle.net/10366/172695 [EN]Categorical data analysis offers valuable tools for evaluating school-based prevention programs, yet these methods remain rarely applied in cyberbullying research. This literature review examined how categorical approaches, including contingency tables and related techniques, have been used in studies evaluating school-based cyberbullying prevention. A comprehensive search was conducted in Web of Science covering publications from 2020 to 2025, yielding 100 articles. After applying predefined inclusion and exclusion criteria, 24 studies were reviewed in full, of which 8 met all requirements for final analysis. The results revealed a predominant reliance on linear statistical techniques, such as t-tests, ANOVA, and regression models, applied mainly to continuous variables. By contrast, categorical analyses were seldom employed. The chi-square test appeared as the most frequent approach, but its use was generally restricted to descriptive purposes, with little application of complementary methods such as standardized residuals, effect size measures, or logistic models. This restricted application reduced the ability to capture response patterns, subgroup differences, and categorical associations essential for evaluating program outcomes. The findings highlight a methodological gap in cyberbullying prevention research and emphasize the potential of categorical data analysis to enrich interpretation. Incorporating these methods could increase methodological rigor, reveal nuanced behavioral patterns, and provide actionable evidence for educators, policymakers, and program designers seeking to strengthen school-based prevention strategies. Thu, 01 Jan 2026 00:00:00 GMT http://hdl.handle.net/10366/172695 2026-01-01T00:00:00Z http://hdl.handle.net/10366/171901 [EN] Background: Loneliness has emerged as a psychosocial issue in oncology, with implications for emotional well- being, social and daily functioning, and adaptation to illness. However, its relationship with perceived social support and functional independence in patients with cancer remains insufficiently characterized. Objective: To analyze loneliness in patients with cancer and its association with sociodemographic, psychosocial, and functional variables. Methods: We conducted a cross-sectional study in 153 adults with cancer recruited from the onco-haematology day hospital at the Complejo Asistencial Universitario de Salamanca, Spain. Global loneliness was assessed with the UCLA Loneliness Scale, and emotional and social loneliness with the De Jong Gierveld Loneliness Scale. Perceived social support was evaluated with the Duke-UNC Functional Social Support Questionnaire, quality of life with the EORTC QLQ-C30, functional independence with the Barthel Index, and anxiety and depressive symptoms with the Hospital Anxiety and Depression Scale (HADS). Correlation analyses and multivariable linear and logistic regression models were performed. Results: The median UCLA loneliness score was 36 (range 20–79), indicating variability in perceived loneliness. Higher loneliness was associated with lower perceived social support, greater depressive and anxiety symptoms, and lower functional independence. In multivariable analyses, perceived social support and functional independence remained independently associated with lower loneliness, while depressive symptoms were associated with higher loneliness only in the linear model. Conclusions: Loneliness was more closely associated with psychosocial and functional than sociodemographic variables. These findings support loneliness assessment in comprehensive cancer care and suggest that social support and functional status may be key loneliness correlates. [ES] Antecedentes: La soledad ha emergido como un problema psicosocial en oncología, con implicaciones en el bienestar emocional, el funcionamiento social y diario, y la adaptación a la enfermedad. Sin embargo, su relación con el apoyo social percibido y la independencia funcional en pacientes con cáncer sigue sin estar suficientemente caracterizada. Objetivo: Analizar la soledad en pacientes con cáncer y su asociación con variables sociodemográficas, psicosociales y funcionales. Métodos: Se realizó un estudio transversal en 153 adultos con cáncer reclutados en el hospital de día de oncohematología del Complejo Asistencial Universitario de Salamanca, España. La soledad global se evaluó con la Escala de Soledad de la UCLA, y la soledad emocional y social con la Escala de Soledad de De Jong Gierveld. El apoyo social percibido se evaluó con el Cuestionario de Apoyo Social Funcional Duke-UNC, la calidad de vida con el EORTC QLQ-C30, la independencia funcional con el Índice de Barthel, y los síntomas de ansiedad y depresión con la Escala de Ansiedad y Depresión Hospitalaria (HADS). Se realizaron análisis de correlación y modelos de regresión lineal y logística multivariante. Resultados: La mediana de la puntuación de soledad de la UCLA fue de 36 (rango 20–79), lo que indica variabilidad en la soledad percibida. Una mayor soledad se asoció con un menor apoyo social percibido, mayores síntomas de depresión y ansiedad, y una menor independencia funcional. En los análisis multivariantes, el apoyo social percibido y la independencia funcional se mantuvieron asociados de forma independiente con una menor soledad, mientras que los síntomas depresivos se asociaron con una mayor soledad solo en el modelo lineal. Conclusiones: La soledad se asoció más estrechamente con las variables psicosociales y funcionales que con las sociodemográficas. Estos hallazgos respaldan la evaluación de la soledad en la atención integral del cáncer y sugieren que el apoyo social y el estado funcional pueden ser correlatos clave de la soledad. Sat, 13 Jun 2026 00:00:00 GMT http://hdl.handle.net/10366/171901 2026-06-13T00:00:00Z http://hdl.handle.net/10366/171684 [EN]Background: University students represent a high-risk population for psychological distress. While body dissatisfaction has emerged as a critical determinant of well-being, a comprehensive synthesis of contemporary evidence, mediating mechanisms, and systemic gaps is required to inform clinical practice. Objectives: To synthesize the scientific literature on body self-perception and mental health in university students, identifying core findings, mediating pathways, and existing research gaps. Methods: Following the PCC (Population, Concept, and Context) eligibility framework, a scoping review was conducted (March–April 2025), following the PRISMA-ScR guidelines. A systematic search was performed across Scopus, PubMed/MEDLINE, PsycINFO, SciELO, and Redalyc databases, including studies from 2014 to 2025 in English and Spanish. Eligibility criteria encompassed peerreviewed quantitative, qualitative, and mixed-methods studies, as well as previous reviews; grey literature and unpublished theses were excluded. Two researchers performed independent data selection and extraction, followed by a narrative synthesis of the evidence. Full search strings are available as Supplementary material. In accordance with PRISMA-ScR guidelines for scoping reviews, formal quality appraisal of the included studies was not performed. Results: A total of 18 studies were included, which were categorized into four thematic clusters. Body dissatisfaction was consistently associated with elevated levels of depression and anxiety across diverse cultural contexts. Self-esteem and fear of negative evaluation were identified as primary mediators. Furthermore, dissatisfaction was significantly linked to suicidal ideation, impaired sleep quality, and social dysfunction. Methodologically, most studies utilized cross-sectional, quantitative designs and remained anchored in the gender binary, largely excluding gender-diverse populations. Conclusion: Body dissatisfaction is a potent risk factor for severe psychological distress in university students, driven by complex cognitive and digital mediators. There is an urgent need for longitudinal research and the inclusion of underrepresented populations. Findings highlight that Higher Education Institutions must transition toward proactive mental health frameworks, including integrated screening and inclusive, gender-affirming counseling policies. Systematic review registration: https://osf.io/6zefc Wed, 13 May 2026 00:00:00 GMT http://hdl.handle.net/10366/171684 2026-05-13T00:00:00Z http://hdl.handle.net/10366/170700 [EN Children who suffer from congenital heart defects (CHDs) have a decreased ability to perform physical exercise and consequently have a decrease in their functional capacity. The main causes of this decrease in functional capacity have been related on the one hand to residual hemodynamic defects and, at the same time, to a situation of physical deconditioning due to inactivity, as well as problems in lung function, especially the presence of restrictive patterns that influence the amount of O2 insufflated (decreased maximum VO2), consequently generating a deficient maximum O2 consumption and maximum work rate. This represents an important prognostic value, since it constitutes an independent predictor of death and hospitalization. This study aims to determine the benefits obtained regarding respiratory function, exercise capacity, and quality of life after implementing a hospital-based cardio-respiratory rehabilitation program compared to a home-based Cardio-respiratory Physical Activity Program in patients with intervened CHDs. Methods: This is a randomized controlled trial on the effectiveness of two different rehabilitation programs on respiratory function, exercise capacity, and quality of life in patients with CHDs conducted at the Child Cardiology and Congenital Heart Disease Unit of the University Hospital Complex of A Coruña (CHUAC). There will be two groups: Cardio-respiratory rehabilitation group program conducted in a face-to-face format at the hospital (n = 26) and a study group that follows a home-based Cardio-respiratory Physical Activity Program (TELEA) (n = 26). The measurement variables will be respiratory function, forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), maximum expiratory flow (PEF), the Tiffeneau index (FEV1 /FVC), forced expiratory flow (FEF25%, FEF50%, FEF75%, FEF25-75%), exercise capacity (peak VO2), and the quality of life of these children and their families. Conclusions: The implementation of cardiac and pulmonary rehabilitation programs in children with CHDs is essential to improve their quality of life, exercise tolerance, and socialization. These programs optimize life expectancy and promote integration, being crucial for their physical and emotional well-being. Sun, 26 Jan 2025 00:00:00 GMT http://hdl.handle.net/10366/170700 2025-01-26T00:00:00Z http://hdl.handle.net/10366/170699 [EN]Introduction/Objectives: Restless legs syndrome (RLS), a chronic neurological disorder related to brain iron metabolism, has been linked to immune-mediated inflammatory conditions such as psoriatic arthritis (PsA). However, the role that inflammation plays in this association and the impact of RLS on PsA outcomes remain unclear. This study aims to investigate the association between RLS and inflammatory/clinical parameters in PsA patients. Materials and Methods: In this cross-sectional study, 230 PsA patients completed the International Restless Legs Syndrome Study Group (IRLSSG) screening questionnaire, with diagnoses confirmed by a neurologist. Data collected included clinical features, disease activity, and comorbidities (obesity, anxiety, depression, insomnia, and fibromyalgia). Results: In total, forty-six patients met the IRLSSG criteria (20%). Those with RLS more frequently had polyarthritis (27% vs. 6%; p < 0.001), more swollen joints (2.0 vs. 1.4; p = 0.04), greater psoriatic involvement (5.7 vs. 3.6; p < 0.001), greater fatigue (39.0 vs. 30.5; p < 0.001), and greater disease activity (14.5 vs. 10.5; p < 0.001). They also exhibited increased disease impact (4.7 vs. 2.9; p < 0.001), poorer functioning (0.7 vs. 0.5; p = 0.01), and higher levels of anxiety (8.0 vs. 5.5; p < 0.001), depression (6.5 vs. 3.9; p < 0.001), and sleep disturbance (13.9 vs. 8.7; p < 0.001). Skin lesions and polyarthritis explained nearly 40% of RLS cases (Odds Ratio (OR) 1.4; 95% Confidence Interval (CI) 1.03-2.0; p = 0.03 and OR 1.03; 95% CI 1.00-1.9; p = 0.04). Conclusions: Psoriatic activity and inflammation may contribute to RLS in PsA. The coexistence of RLS was associated with greater disease activity, greater disease impact, and more emotional and sleep-related comorbidities. Wed, 10 Dec 2025 00:00:00 GMT http://hdl.handle.net/10366/170699 2025-12-10T00:00:00Z http://hdl.handle.net/10366/170698 [EN]Telomere length (TL) is a marker of cellular health and aging. Physical exercise has been associated with longer telomeres and, therefore, healthier aging. However, results supporting such effects vary across studies. Our aim was to synthesize existing evidence on the effect of different modalities and durations of physical exercise on TL. The aim of this study was to explore the needs and expectations of individuals with physical disabilities and their interventionists for the use of a virtual reality physical activity platform in a community organization. We performed an umbrella review and meta-analysis. Data sources included PubMed, Embase, Web of Science, Cochrane Library, and Scopus. We selected systematic reviews and meta-analyses of randomized and nonrandomized controlled clinical trials evaluating the effect of physical exercise on TL. Our literature search retrieved 12 eligible systematic reviews, 5 of which included meta-analyses. We identified 22 distinct primary studies to estimate the overall effect size of physical exercise on TL. The overall effect size was 0.28 (95% CI 0.118-0.439), with a heterogeneity test value Q of 43.08 (P=.003) and I² coefficient of 51%. The number of weeks of intervention explained part of this heterogeneity (Q_B=8.25; P=.004), with higher effect sizes found in studies with an intervention of less than 30 weeks. Exercise modality explained additional heterogeneity within this subgroup (Q_B=10.28, P=.02). The effect sizes were small for aerobic exercise and endurance training, and moderate for high-intensity interval training. Our umbrella review and meta-analysis detected a small-moderate positive effect of physical exercise on TL, which seems to be influenced by the duration and type of physical exercise. High quality studies looking into the impact of standardized, evidence-based physical exercise programs on TL are still warranted. Fri, 10 Jan 2025 00:00:00 GMT http://hdl.handle.net/10366/170698 2025-01-10T00:00:00Z http://hdl.handle.net/10366/170697 [EN]The population of people over the age of 65 is currently growing thanks to social and health policies. It presents an increase in age-related diseases due to a series of morphological and physiological changes in these population groups. We aimed to study the effect of a physical exercise program on memory and learning. A quasi-experimental pilot study carried out with a sample of 73 healthy female subjects who were divided into two groups: an intervention group and a control group. Both groups underwent a neuropsychological evaluation before and after the intervention. Subjects in the intervention group performed physical exercise 3 times a week, 50 min each session. The subjects in the control group did not perform any type of physical exercise and completed their daily life activities. The intervention group improvement in cognitive functions after the intervention and obtained higher scores against the control group. Regular physical exercise improves global cognitive function, visoconstructive capacity, and memory functions. The online version contains supplementary material available at 10.1186/s12877-025-06614-0. Fri, 05 Dec 2025 00:00:00 GMT http://hdl.handle.net/10366/170697 2025-12-05T00:00:00Z http://hdl.handle.net/10366/170013 [EN]We provide a non-parametric computing-intensive method to test the statistical significance of the rolling window correlation for bi-variate time series. This method (test) addresses the effects due to the multiple testing (inflation of the Type I error) when the statistical significance is estimated for the rolling window correlation coefficients. We follow Telford and Polanco-Martínez to carry out the proposed method. The method is based on Monte Carlo simulations by permuting one of the variables (dependent) under analysis and keeping fixed the other variable (independent). We improve the computational time of this method to reduce the computation time (speedup was up to practically five times faster than the sequential method using 11 cores) through parallel computing. We compare the results obtained through the proposed method with two p-value correction methods frequently used (Bonferroni and Benjamini and Hochberg –BH) after being applied to synthetic and to real-life ecological time series. Our results show that the proposed method works roughly similar to these two p-value correction methods, especially with the method of BH, but our test is a little more restrictive than BH and a little more permissive than Bonferroni. The test is programmed in R and is included in the package NonParRolCor that is available freely on CRAN. Wed, 01 Sep 2021 00:00:00 GMT http://hdl.handle.net/10366/170013 2021-09-01T00:00:00Z http://hdl.handle.net/10366/170012 [EN]RolWinMulCor estimates the rolling window correlation for bi- and multi-variate cases between regular time series, with particular emphasis on ecological data. It is based on the concept of rolling, running or sliding window correlation, being useful for evaluating the evolution and stability of correlation over time. RolWinMulCor contains six functions to estimate and to plot the correlation coefficients and their respective p-values. The first two focus on the bi-variate case: (1) rolwincor_1win and (2) rolwincor_heatmap, estimate the correlation coefficients and the p-values for only one window-length (time-scale) and considering all possible window-lengths or a band of window-lengths, respectively. The second two functions: (3) rolwinmulcor_1win and (4) rolwinmulcor_heatmap, are designed to analyze the multi-variate case, following the bi-variate case to visually display the results, but these two approaches are methodologically different (the multi-variate case estimate the adjusted coefficients of determination instead of the correlation coefficients). The last two functions: (5) plot_1win and (6) plot_heatmap, are used to represent graphically the outputs of the four aforementioned functions as simple plots or as heat maps. The functions contained in RolWinMulCor are highly flexible, containing several parameters for controlling the estimation of correlation and the features of the plot output. The RolWinMulCor package also provides examples with synthetic and real-life ecological time series for illustrating its use. Sun, 01 Nov 2020 00:00:00 GMT http://hdl.handle.net/10366/170012 2020-11-01T00:00:00Z http://hdl.handle.net/10366/169699 [EN]The aim of this study was to analyze the relationship between healthy vascular aging (HVA) and the Mediterranean diet alongside other lifestyles in a Spanish population aged 35 to 75 years without previous cardiovascular diseases. In this cross-sectional descriptive study, 501 individuals aged 35 to 75 years were recruited from five health centers by random sampling stratified by age and sex (55.90 ± 14.24 years, 49.70% men). HVA was determined in two steps. Step 1: Subjects with vascular damage to the carotid arteries or peripheral arterial disease were classified as non-HVA. Step 2: The study population was classified by age and sex using the percentiles of the vascular aging index (VAI), with VAI ≤p25 considered HVA and >p25 considered non-HVA. The VAI was estimated using the following formula (VAI = (log (1.09) × 10 cIMT + log (1.14) cfPWV) × 39.1 + 4.76. Carotid-femoral pulse wave velocity (cfPWV) was measured with the SphygmoCor® device, and carotid intima-media thickness using Sonosite Micromax® ultrasound. Mediterranean diet (MD) adherence, alcohol and tobacco use were recorded through validated questionnaires. Physical activity was assessed with the ActiGraph-GT3X® accelerometer. The mean VAI value was 61.23 ± 12.86 (men-63.47 ± 13.75 and women-59.04 ± 11.54; p < 0.001). HVA was found in 18.9% (men-19.9% and women-17.8%). In the multiple regression analysis after adjusting for possible confounding factors, the mean VAI value showed a positive association with alcohol use (β = 0.020) and sedentary hours per week (β = 0.109) and a negative association with hours of activity per week (β = -0.102) and with the number of healthy lifestyles (β = -0.640). In the logistic regression analysis, after adjusting for possible confounding factors and compared to those classified as non-HVA, subjects classified as HVA were more likely to show MD adherence (OR = 0.571), do more than 26 h per week of physical activity (OR = 1.735), spend under 142 h per week being sedentary (OR = 1.696), and have more than two healthy lifestyles (OR = 1.877). The results of this study suggest that the more time spent doing physical activity and the less time spent in a sedentary state, the lower the vascular aging index and the greater the likelihood of being classified in the group of subjects with HVA. Mon, 05 Aug 2024 00:00:00 GMT http://hdl.handle.net/10366/169699 2024-08-05T00:00:00Z http://hdl.handle.net/10366/169631 [EN]Although case-control analyses have suggested an additive value with the association of clarithromycin to continuous lenalidomide and dexamethasone (Rd), there are not phase III trials confirming these results. In this phase III trial, 286 patients with MM ineligible for ASCT received Rd with or without clarithromycin until disease progression or unacceptable toxicity. The primary endpoint was progression-free survival (PFS). With a median follow-up of 19 months (range, 0–54), no significant differences in the median PFS were observed between the two arms (C-Rd 23 months, Rd 29 months; HR 0.783, p = 0.14), despite a higher rate of complete response (CR) or better in the C-Rd group (22.6% vs 14.4%, p = 0.048). The most common G3–4 adverse events were neutropenia [12% vs 19%] and infections [30% vs 25%], similar between the two arms; however, the percentage of toxic deaths was higher in the C-Rd group (36/50 [72%] vs 22/40 [55%], p = 0.09). The addition of clarithromycin to Rd in untreated transplant ineligible MM patients does not improve PFS despite increasing the ≥CR rate due to the higher number of toxic deaths in the C-Rd arm. Side effects related to overexposure to steroids due to its delayed clearance induced by clarithromycin in this elderly population could explain these results. The trial was registered in clinicaltrials.gov with the name GEM-CLARIDEX: Ld vs BiRd and with the following identifier NCT02575144. The full trial protocol can be accessed from ClinicalTrials.gov. This study received financial support from BMS/Celgene. Fri, 01 Jan 2021 00:00:00 GMT http://hdl.handle.net/10366/169631 2021-01-01T00:00:00Z http://hdl.handle.net/10366/169627 [EN]Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of rare lymphoid malignancies that mostly have poor prognoses with currently available treatments. Upfront consolidation with autologous stem cell transplantation (ASCT) is frequently carried out, but its efficacy has never been investigated in randomized trials. We designed a multicenter, international, retrospective study with the main objective of comparing progression-free survival and overall survival of patients with PTCL who underwent ASCT in complete remission (CR) after first-line chemotherapy with a control group who did not undergo ASCT. From the initial population of 286 registered patients, 174 patients with PTCL other than anaplastic large cell lymphoma, ALK-positive, deemed fit for ASCT at the time of diagnosis, and who were in CR or uncertain CR after induction therapy (CR1) were included in our analysis. one hundred and three patients underwent ASCT, whereas 71 did not, in most cases (n=53) because the physician decided against it. With a median follow-up of 65.5 months, progression-free survival was significantly better in the transplanted patients than in the non-transplanted group: 63% versus 48% at 5 years (P=0.042). Overall survival was significantly longer for ASCT patients in the subgroup with advanced stage at diagnosis (5-year overall survival: 70% vs. 50%, P=0.028). In the multivariate analysis, first-line ASCT was associated with significantly prolonged progression-free survival (HR=0.57, 95% CI: 0.35-0.93) and overall survival (HR=0.57, 95% CI: 0.33-0.99). In conclusion, our study supports the use of ASCT as a consolidation strategy for patients with PTCL in CR1. These results should be confirmed in a prospective randomized study. Sat, 01 Jan 2022 00:00:00 GMT http://hdl.handle.net/10366/169627 2022-01-01T00:00:00Z http://hdl.handle.net/10366/169620 [EN]The prevalence of hereditary bleeding disorders (HBDs) in heavy menstrual bleeding (HMB) and their impact on health-related quality of life (HRQoL) remain underexplored. We investigated the HRQoL of women with non-structural HMB and its association with HBDs. Method A prospective longitudinal study of 100 women with HMB without structural gynecological pathology. HMB was defined as ≥ 8 days of bleeding or a PBAC score > 100 points. Four HRQoL questionnaires —SF-12®v2, EQ-5D-3 L, MBQ, and SAMANTA— were administered at baseline and 6 months. HBD diagnosis included hypermobility spectrum disorders, von Willebrand disease, platelet disorders, congenital coagulation factor deficiencies, and hyperfibrinolysis. Result 88 women required treatment for HMB, anemia, or iron deficiency. Combined hormonal therapy (43%) and levonorgestrel intrauterine devices (14%) were the most frequently used treatments. Thirty-one women (31%) were diagnosed with HBD. After 6 months of treatment, SF-12®v2 results showed significant improvements in the mental and physical health components, particularly with respect to mobility, moderate activities, and pain perception. EQ-5D-3 L evaluations revealed significant improvements in anxiety and depression. MBQ and SAMANTA scores indicated significant reductions in menstrual bleeding and enhanced quality of life. However, at T6, HBD patients showed significantly lower improvements compared with non-HBD patients in physical health (SF-12 PCS, p = 0.035), EQ-5D index scores (p = 0.024), PBAC (p = 0.049), and MBQ (p = 0.028). Conclusion HBD is an important cause of HMB. Medical treatment improves mobility, moderate activities, pain perception, and anxiety/depression after 6 months, although HRQoL improvements are less pronounced in HBD patients. Thu, 29 Jan 2026 00:00:00 GMT http://hdl.handle.net/10366/169620 2026-01-29T00:00:00Z