TY  - JOUR 
AU  - Colado, Enrique
AU  - Paíno Gómez, María Teresa
AU  - Maiso, Patricia
AU  - Ocio San Miguel, Enrique M.
AU  - Chen, Xi
AU  - Álvarez Fernández, Stela
AU  - Gutiérrez Gutiérrez, Norma Carmen
AU  - Martín-Sánchez, Jesús
AU  - Flores Montero, Juan Alejandro
AU  - San Segundo, Laura
AU  - Garayoa Berrueta, Mercedes
AU  - Fernández Lázaro, Diego
AU  - Vidriales Vicente, María Belén
AU  - Galmarini, Carlos M
AU  - Avilés, Pablo
AU  - Cuevas, Carmen
AU  - Pandiella Alonso, Atanasio
AU  - San Miguel Izquierdo, Jesús Fernando
PY  - 2011
SN  - 0390-6078
UR  - http://hdl.handle.net/10366/154951
AB  - [EN]Although the majority of patients with acute myeloid leukemia initially respond to conventional chemotherapy, relapse is still the leading cause of death, probably because of the presence of leukemic stem cells that are insensitive to current...
LA  - eng
PB  - Ferrata Storti Foundation
KW  - Zalypsis
KW  - Leukemia
KW  - DNA damage response
KW  - Reverse Transcriptase Polymerase Chain Reaction
KW  - Mitochondria
KW  - Leukemia
KW  - Flow Cytometry
KW  - Gene Expression Regulation
KW  - Humans
KW  - DNA Damage
KW  - Cell Line
KW  - Tetrahydroisoquinolines
KW  - Antineoplastic Agents
KW  - Caspases
KW  - Oligonucleotide Array Sequence Analysis
KW  - Cell Proliferation
KW  - Cell Survival
KW  - Apoptosis
KW  - Gene Expression Profiling
KW  - Rad51 Recombinase
KW  - DNA Breaks
KW  - HL-60 Cells
KW  - BRCA1 Protein
KW  - Stem Cells
TI  - Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response
DO  - 10.3324/haematol.2010.036400
T2  - Haematologica
VL  - 96
M2  - 687
ER  -