TY  - JOUR 
AU  - Olaizola, Irene
AU  - Odriozola-Gimeno, Mikel
AU  - Olaizola, Paula
AU  - Caballero-Camino, Francisco J
AU  - Pastor-Toyos, Noelia
AU  - Tena-Garitaonaindia, Mireia
AU  - Lapitz, Ainhoa
AU  - Val, Beatriz
AU  - Guimaraes, Amanda R
AU  - Asensio Martín, Maitane
AU  - Huici-Izagirre, Maider
AU  - Rae, Colin
AU  - de Sancho, David
AU  - Lopez, Xabier
AU  - Rodrigues, Pedro M
AU  - Herráez Aguilar, Elisa
AU  - Briz Sánchez, Oscar
AU  - Izquierdo-Sanchez, Laura
AU  - Eleta-Lopez, Aitziber
AU  - Bittner, Alexander M
AU  - Martinez-Amesti, Ana
AU  - Miranda, Teresa
AU  - Ilyas, Sumera I
AU  - Braconi, Chiara
AU  - Perugorria, Maria J
AU  - Bujanda, Luis
AU  - Rivilla, Iván
AU  - Marin, Jose J G
AU  - Cossío, Fernando P
AU  - Banales, Jesus M
PY  - 2025
SN  - 0168-8278
UR  - http://hdl.handle.net/10366/170068
AB  - [EN]Patients with cholangiocarcinoma (CCA) have poor prognosis. Current cisplatin-based first-line chemotherapy offers limited survival benefit. Cisplatin induces single-strand DNA breaks, activating DNA repair mechanisms that diminish its...
LA  - eng
PB  - Elsevier B.V.
KW  - Cancer
KW  - Chemoresistance
KW  - Chemotherapy
KW  - DNA damage
KW  - Cisplatin
KW  - Cholangiocarcinoma
KW  - Xenograft Model Antitumor Assays
KW  - Humans
KW  - Cell Line
KW  - Antineoplastic Agents
KW  - Bile Duct Neoplasms
KW  - DNA Repair
KW  - Drug Resistance
KW  - Apoptosis
KW  - Animals
KW  - DNA Breaks
KW  - Mice
TI  - New platinum derivatives selectively cause double-strand DNA breaks and death in naïve and cisplatin-resistant cholangiocarcinomas
DO  - 10.1016/J.JHEP.2025.04.034
T2  - Journal of Hepatology
VL  - 83
M2  - 1077
ER  -