TY  - JOUR 
AU  - Martín Bejarano, Paloma
AU  - Sánchez Tapia, Eva María 
AU  - Pérez, Jessica
AU  - Martín Gómez, María Teresa
AU  - Vidal Tocino, Rosario
AU  - González Sarmiento, Rogelio
AU  - Herrero Hernández, Ana Belén
PY  - 2025
SN  - 1456-542X
UR  - http://hdl.handle.net/10366/170173
AB  - [EN]Inherited mutations in BRCA1 are among the primary causes of hereditary breast and ovarian cancer (HBOC). Genetic testing has identified numerous pathogenic and benign mutations in BRCA1, but also thousands of variants of uncertain significance...
LA  - eng
PB  - Springer Nature Link
KW  - BRCA1
KW  - Genetic counseling
KW  - VUS
KW  - Homologous recombination
KW  - DSBs
KW  - Olaparib
KW  - Genetic Counseling
KW  - Genetic Predisposition to Disease
KW  - Genes, BRCA1
KW  - Mutagenesis, Site-Directed
KW  - Risk Assessment
KW  - Genetic Testing
KW  - Humans
KW  - Cell Line, Tumor
KW  - Hereditary Breast and Ovarian Cancer Syndrome
KW  - Radiation Tolerance
KW  - Drug Resistance, Neoplasm
KW  - Poly(ADP-ribose) Polymerases
KW  - BRCA1 Protein
KW  - Recombinational DNA Repair
TI  - Functional characterization of BRCA1 variants of unknown significance using homologous recombination repair assays.
DO  - 10.1186/s13058-025-02125-3
T2  - Breast Cancer Research
VL  - 27
M2  - 174
ER  -