TY  - JOUR 
AU  - Rodríguez Sánchez, Alberto
AU  - Quijada Álamo, Miguel
AU  - Pérez Carretero, Claudia
AU  - Herrero Hernández, Ana Belén
AU  - Arroyo-Barea, Andrés
AU  - Dávila-Valls, Julio
AU  - Rubio, Araceli
AU  - García de Coca, Alfonso
AU  - Benito Sánchez, Rocío
AU  - Rodríguez Vicente, Ana E.
AU  - Hernández Rivas, Jesús María
AU  - Hernández Sánchez, María
PY  - 2025
UR  - http://hdl.handle.net/10366/171544
AB  - [EN]Chronic lymphocytic leukemia (CLL) is a clinically and genetically heterogenous disease. Recent next-generation sequencing (NGS) studies have uncovered numerous low-frequency mutated genes in CLL patients, with SAMHD1 emerging as a candidate...
LA  - eng
KW  - Leukemia, Lymphocytic, Chronic, B-Cell
KW  - SAM Domain and HD Domain-Containing Protein 1
KW  - DNA Damage
KW  - Poly(ADP-ribose) Polymerase Inhibitors
KW  - Humans
KW  - Mutation
KW  - Female
KW  - Male
KW  - BRCA1 Protein
KW  - Middle Aged
KW  - Aged
KW  - CRISPR-Cas Systems
KW  - Cell Line, Tumor
KW  - Aged
KW  - Mutation
KW  - Leukemia
KW  - CRISPR-Cas Systems
KW  - Humans
KW  - DNA Damage
KW  - BRCA1 Protein
KW  - Cell Line
KW  - Middle Aged
TI  - SAMHD1 dysfunction impairs DNA damage response and increases sensitivity to PARP inhibition in chronic lymphocytic leukemia
DO  - 10.1038/s41598-025-93629-7
T2  - Scientific reports
VL  - 15
M2  - 10446
ER  -